3EFFECT OF G.13700A>G AND G.25783C>T IN PIT-1 GENE ON GROWTH TRAITS OF DUROC, LANDRACE, YORKSHIRE PIG | [Journal of Animal and Plant sciences • 2023]

Author(s):

1. X. Dong: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

2. Z. Liu: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

3. X. Wang: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

4. Q. Chen: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

5. G. Bai: Dehong Animal Husbandry Station, Dehong 679399, Yunnan, China

6. G. Lan: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

7. Q. Wang: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

8. M. Li: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

9. D. Yan: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

10. S. Lu: Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China

Abstract:

Pituitary specific transcription factor-1 (Pit-1) gene is responsible for pituitary development and growth hormone expression, which is considered a pivotal candidate gene for growth in pig. This study aims to detect novel single nucleotide polymorphisms (SNPs) in porcine Pit-1 gene, investigate its effect on growth traits in the Duroc, Landrace and Yorkshire pigs. Two novel polymorphisms were detected, one located in the intron 2 (g. 13700 A>G) and another located in exon 4 (g.25783 C>T) which caused an amino acid change from threonine to methionine (Thr36Met). At g.13700 A>G site, the frequency of A allele was higher than G allele in Duroc, Landrace and Yorkshire. At the g.25783 C>T site, it was remarkable differences in allelic frequencies and genotypic frequencies among the three pig breeds. This study demonstrated the significant genotype effect of Pit-1 on body weights at 70 d, age when reached 30kg, 50kg, 100kg and average daily gain from 30kg to 100kg. According to our results, the novel Pit-1 polymorphisms may be useful in pig selection as molecular markers and required in future studies.

Page(s): 1286-1291

DOI: 10.36899/JAPS.2023.6.0668

Published: Journal: Journal of Animal and Plant sciences, Volume: 33, Issue: 6, Year: 2023

Keywords:

growth traits , polymorphisms , Pit1 , Pig

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