Abstract:
Homeopathic practitioners have reported the specific effects of various potentized and diluted drugs (Chand, 1995 and Taylor, 1998) since long time. On the basis of this concept they are treating various diseases with confidence and success. However, the scientific basis for this concept is not available in the research. literature involving isolated tissues. In the present study, the dilutions of Acetylcholine (ACh) prepared in deionized water have been tested on electrical and mechanical activity of isolated rabbit`s- heart for both simple dilutions (SD) and succussed dilutions (SUD). Results demonstrated that the difference in the effect of SD and SUD was found significant at 9x and 3x for systolic force and at 2x for heart rate, duration of action potential and duration of phase 4. However, both the SD and SUD of ACh could produce` opposite to the normal effect in different dilutions on heart rate, systolic force, duration of cardiac action potential and its phase 4. It is concluded that SD and SUD differ in properties and effects on isolated tissue. Further, a drug in both the SD and SUD can change its configuration due to interaction with water and air at its surface (Simson, 1909) to produce opposite effect than its normal one.
Page(s):
1-8
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Pharmacy, Volume: 21, Issue: 1, Year: 2004