Tongue cancer developing after haematopoietic stem cell transplantation for treatment of acute promyelocytic leukaemia: A case report | [Journal of Pakistan Medical Association • 2024]

Author(s):

1. Hisataka Kitano: Department of Dentistry, School of Medicine, Nihon University, Tokyo, Japan

2. Souichi Aizawa: Department of Dentistry, Yokohama Chuo Hospital, Kanagawa, Japan

3. Emily Chang: Department of Dentistry, School of Medicine, Nihon University, Tokyo, Japan

4. Kanako Yamagata: Department of Dentistry, Yokohama Chuo Hospital, Kanagawa, Japan

5. Hiromasa Takayama: Department of Dentistry, Yokohama Chuo Hospital, Kanagawa, Japan

6. Tempei Kawano: Department of Dentistry, School of Medicine, Nihon University, Tokyo, Japan

Abstract:

Acute promyelocytic leukaemia (APL) is a form of acute myelogenous leukaemia. APL is characterised by anaemia due to suppression of normal haematopoiesis and infection. Haematopoietic stem cell transplantation (HSCT) is current option for the treatment of haematopoietic malignancies and is proving to be successful. Although HSCT has been effective for the treatment of haematopoietic malignant tumours, chronic graft-versushost disease (GVHD) but secondary cancers can occur, which is a serious complication and frequently involves the oral cavity and skin. Here, we report the case of tongue cancer occurring 17 years after transplantation in a patient who developed GVHD after haematopoietic stem cell transplantation and APL remission. To the best of our knowledge, this is the first report of secondary oral cancer after HSCT with APL as the primary disease.

Page(s): 984-986

DOI: 10.47391/JPMA.9770

Published: Journal: Journal of Pakistan Medical Association, Volume: 74, Issue: 5, Year: 2024

Keywords:

Oral Squamous Cell Carcinoma , Chronic graft versus host disease , Secondary cancer , Haematopoietic stem cell transplantation

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