Abstract:
Oral dosage forms must initially undergo dissolution, and although the decrease in stomach acid production which accompanies increasing age has sometimes been cited as a factor mitigating against adequate drug absorption, while there is no real evidence for such an effect. It is quite possible that the only clinically important aspect of gastric pH as regards drug absorption is that it effects gastric motility, with higher pH values favoring absorption by hastening the movement of stomach contents to the small intestine. The role of gastric pH in drug absorption has already been discussed in the previous attempts (Sultana and Arayane 1982). The present review describes the progress that has been made in understanding the effect of age on drug handling system of the body and the implication that these changes have on the utility of pharmacological agents in the treatment of old age patients.
Page(s):
79-92
DOI:
DOI not available
Published:
Journal: International Journal of Pharmacology, Volume: 10, Issue: 1, Year: 1993