The efficacy of a single dose of pethidine, fentanyl and morphine in treating postanesthesia shivering. | [Pakistan Journal of Pharmaceutical Sciences • 2011]

Author(s):

1. Shideh Dabir: Department of Anesthesiology and Critical Care, Tracheal Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Maryam Jahandideh: College of Pharmacy, Islamic Azad University, Tehran Medical, Iran

3. Mohammad Abbasinazari: Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4. Homeyra Kouzekanani: Department of Anesthesiology and Critical Care, Shohada - Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Tahereh Parsa: Department of Anesthesiology and Critical Care, National Research Institute of Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6. Badiozaman Radpay.: Department of Anesthesiology and Critical Care, Lung Transplant Research Center, National Research Institute of Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Postanesthesia shivering is an undesirable event that may induce a variety of adverse consequences including patient discomfort, increased oxygen consumption and wound pain. Thus, its pharmacological treatment should be regarded. The purpose of this study was to compare the efficacy of morphine, fentanyl and pethidine for the treatment of postanesthesia shivering. Fifty patients who developed shivering were treated in a randomized double blinded manner with an intravenous bolus dose of 2 or 4 mg morphine, 25 or 50 mg pethidine, and 50 Î¼g fentanyl. Then, they were monitored for 30 minutes and the shivering suppression grade, the time taken to stop shivering, the shivering cessation time, recurrence of shivering and opioid side effects were evaluated. Core body temperature was measured immediately before, and at 15 and 30 minute after administering the drug. The groups did not differ significantly regarding shivering suppression grade, shivering cessation time, and recurrence of shivering. There was a significant difference in the time taken to stop shivering between groups. Following injection of the drugs, the core temperatures increased in the five groups with statistical difference. All opioids were effective in treating postanesthesia shivering in a similar extent

Page(s): 513-517

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 24, Issue: 4, Year: 2011

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