The pathophysiology of repurposed antiviral drugs for treatment of COVID-19 infection | [Life and Science • 2020]

Author(s):

1. Adnan Haider: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

2. Muhammad Faheem: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

3. Syed Babar Jamal: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

4. Muhammad Naeem: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

5. Atif Ali Khan Khalil: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

6. Raees Khan: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

7. Fazli Subhan: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

Abstract:

Our planet earth has seen many viral pandemics The most recent pandemic was Severe Acute Respiratory Syndrome (SARS-CoV-2) commonly called Corona Virus disease (COVID-19). It was first reported inWuhan Peoples Republic of China, in December 2019. COVID-19 is a positive-sense single-strand enveloped RNA virus mainly found in mammals. To date, a total of six species of coronavirus have been reported that affected humans. These mainly cause respiratory, hepatic, enteric, and neurological complications. Since it is a novel virus, different therapies were used for the treatment These measures comprised of mostly repurposing of already available drugs, more specifically antiviral drugs. In this review article, we have summarized the virushost relation and chemical structure and also discussed in detail the proposed mechanism of these repurposed antivirals drugs.

Page(s): 32-37

DOI: 10.37185/LnS.1.1.155

Published: Journal: Life and Science, Volume: 1, Issue: SI, Year: 2020

Keywords:

COVID19 , COVID19 , Virus , Cytokin Storm , Therapeutic Drugs

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