Abstract:
Background Facial skin aging is a progressive, multifactorial and complex processes that greatly affects appearance so many people try to postpone this process. In North Sumatra, the passion fruit purple variant (Passiflora edulis Sims var. edulis) is commonly planted. Piceatannol, ascorbic acid, flavonoids, resveratrol, and sterols found in industrial waste seeds play a role in alleviating the appearance of skin aging via antioxidant, anti-inflammatory, tyrosinase inhibition, promoting fibroblast proliferation, and collagen formation. The objective of this study was to determine the effect of 3% passion fruit purple variant seed extract cream on facial skin aging. Methods This pre-experimental clinical trial study was conducted on 40 participants with facial skin aging. History and clinical evaluation utilizing the Dermoscopic Photoaging Scale (DPAS) following administration of 3% passion fruit purple variant seed extract cream at baseline, weeks 2, 4, 6, and 8 validated the diagnosis. All adverse effects were documented during the course of the trial, and participant satisfaction was evaluated at week 8. Statistical analysis using repeated Anova test was done to evaluate the differences before and after intervention, with p < 0.05 denotes statistical significance. Results There were significant decrease in DPAS score in participants with facial skin aging (p=0.000) after 8 weeks of using passion fruit purple variant seed extract cream. Only 1 out of 40 participants (2.5%) experienced adverse effects of mild and transient dry skin. Most of the participants (82.5%) indicated good satisfaction level. Conclusion Topical use of 3% passion fruit purple variant seed extract cream can improve the appearance of facial skin aging with minimal adverse effects and good satisfaction level.
Page(s):
566-573
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Association of Dermatologists, Volume: 33, Issue: 2, Year: 2023
Keywords:
antioxidant
,
antioxidant
,
Passion fruit seed extract
,
Facial skin aging
,
DPAS