Thiol-disulphide Homeostas1s and Ischemia-modi ed Album1n Level and its Relat1onsh1p with Cl1nicopathological Features of Breast Cancer | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2022]

Author(s):

1. Ugur Hunur: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

2. Zeynep Oruc: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

3. Senar Ebinc: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

4. Idris Oruc: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

5. Salim Neselioglu: Department of Biochemistry, Ankara City Hospital, Ankara, Turkey

6. Abdurrahman Isikdogan: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

Abstract:

Objective: To investigate the status of thiol-disulphide homeostasis and ischemic-modi ed albumin and their association with clinicopathological parameters in breast cancer. Study Design: A cross-sectional descriptive study. Place and Duration of Study: Department of Internal Medicine and Department of Medical Oncology,Dicle University, Turkey, from April to September 2021. Methodology: Forty treatment-naive female patients diagnosed with breast cancer who presented to the Oncology Clinic of the hospital and 33 healthy women with no comorbidities were included. Serum levels of native thiol (NT), disulphide (Ds), total thiol (TT), IMA (ischemic modi ed albumin) at diagnosis and disulphide/native thiol (Ds/NT), disulphide/total thiol (Ds/TT), and the ratios of native thiol/total thiol (NT/TT) were analysed by the colorimetric method. Results: Median age at diagnosis was 44 (29-70) years. The majority of patients had stage II-III disease (77.5%). Mean serum levels of TT were signi cantly lower in breast cancer patients (462.45 ± 100.2 ¼mol/L) compared to healthy controls (507.28 ± 75.72 ¼mol/L) (p=0.038). Mean serum levels ofDs were signi cantly lower in breast cancer patients (20.25 ± 5.94 ¼mol/L) compared to healthy controls (22.99 ± 3.56 ¼mol/L) (p=0.018). Meanwhile, mean IMA levels were signi cantly higher in breast cancer patients (0.81 ± 0.05 ¼mol/L) compared to healthy controls (0.73 ± 0.19 ¼mol/L) (p=0.016). NT and TT levels showed a moderate correlation with the percentage of fat mass and body mass index (BMI), and a weak correlation with age (p<0.05). Univariate and multivariate analyses examining the association between thiol-disulphide levels and patient clinical characteristics demonstrated that NT and TT levels had a statistically signi cant relationship with body mass index and menopausal status (p<0.05), with lower levels of NT and TT in postmenopausal patients and patients with high BMI. Conclusion: Decreased TT and Ds levels and increased IMA levels were determined in patients diagnosed with breast cancer compared to the healthy control group. Thiol-disulphide levels were observed to be associated with clinical characteristics such as menopausal status and BMI.

Page(s): 1435-1440

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 11, Year: 2022

Keywords:

Breast Cancer , Thiol , Ischemic modi ed albumin

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