Alteration of Serum Cystatin-C Levels after Hemodialysis in Dogs with Kidney Disease | [Pakistan Veterinary Journal • 2021]

Author(s):

1. Woonchan Ahn: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University,1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do,South Korea : Smart animal hospital Sinsa,Seoul, 06026,Korea

2. Tae Hyeong Kim: Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University,1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do,South Korea

3. Taeho Lee: Smart animal hospital Sinsa,Seoul, 06026,Korea

4. Jin-Ok Ahn: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University,1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do,South Korea

5. Jung Hoon Choi: Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University,1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do,South Korea

6. Jin-Young Chung: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University,1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do,South Korea

Abstract:

Kidney diseases are common life-threatening diseases in small animals. To evaluate the efficiency of hemodialysis in kidney disease treatment, several lowmolecular-weight biochemical markers can be assessed. Recently, middlemolecular-weight proteins such as cystatin-C have been investigated for use as alternative biomarkers to evaluate renal function and predict mortality, especially in human hemodialysis patients. The goal of this study is to assess changes in cystatin-C levels when performing low-flux hemodialysis with an ultraflux dialyzer in dogs with kidney disease. This was a retrospective study. A total of twenty hemodialysis sessions were included in the study. The concentrations of cystatin-C level before and after hemodialysis were determined by examining ELISA results. The cystatin-C concentration was significantly lower after hemodialysis than before hemodialysis (P=0.0016). Cystatin-C can be removed by using low-flux hemodialysis. Thus, cystatin-C can be considered a potential kidney function biomarker in dogs with kidney disease being treated with low-flux intermittent hemodialysis.

Page(s): 299-302

DOI: 10.29261/pakvetj/2020.100

Published: Journal: Pakistan Veterinary Journal, Volume: 41, Issue: 2, Year: 2021

Keywords:

Hemodialysis , Dog , CystatinC , Kidney disease , Middlemolecularweight proteins

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