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Analgesic and Anti-inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents.
Author(s):
1. Sadia Ghousia Baig: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
2. Muhammad Mohtasheemul Hasan: Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
3. Salman Ahmed: Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
4. Syeda Anum Fatima: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
5. Salma: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Abstract:
The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked with anticancer, antihyperlipidemic, hypoglycemic and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetyl salicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg dose demonstrated analgesic and anti-inflammatory activities but in hot plate results were unreliable as here significant activity started after 90 minutes. For toxicity test 5ml/kg dose was administered orally in mice and no toxicity symptoms were observed. It is therefore concluded that PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.
Page(s): 174-179
DOI: DOI not available
Published: Journal: Journal of Basic and Applied Sciences, Volume: 14, Issue: 0, Year: 2018
Keywords:
NULLL
References:
[1] Romero-ArenasO,Damian HuatoMA,Rivera TapiaJA,Baez SimonA,Huerta Lara M and Cabrera Huerta E.,,2013,and its importance for feeding of rural communities in PuebloMexico,Int Res J Biol Sci,2,59,65
[2] WaniIA,SogiDS,WaniAA,GillBS,ShivhareUS,,2010,Physicochemical properties of starches from Indian Kidney bean (Phaseolus vulgaris) cultivars,Int J Food Sci Technol,45,2176,85
[3] Roman-RamosR,Flores-SaenzJL,Alarcon-AguilarFJ,,2010,,,02379,2621,
[4] Pari L and Venkateswaran S. Effect of an aqueous extract of Phaseolus vulgaris on plasma insulin and hepatic key enzymes of glucose metabolism in experimental diabetes. Pharmazie 2003; 58(12): 916-19.
[5] Hayat I, Ahmad A, Masud T, Ahmed A & Bashir S. Nutritional and Health Perspectives of Beans (Phaseolus vulgaris L.): An Overview, Critical Reviews in Food Science and Nutrition 2014; 54 (5): 580-92. https://doi.org/10.1080/
[6] Siddiq M, Ravi R, Dolan KD. Physical and functional characteristics of selected dry bean (Phaseolus vulgaris L.) flour. LWT-Food Sci Technol 2010; 43: 232-37.
[7] GolobT,KacM,PlestenjakA,,2003,Dietary fibre content of dry and processed beans,Food Chem,80,231,35
[8] CostaGEA,Queiroz-MoniciKS,ReisSMPM,OliveiraAC,,,,,8146,00258,
[9] BeningerCW,HosfieldGL,,2003,Antioxidant activity of extracts, condensed tannin fractions, and pure flavonoids from Phaseolus vulgaris L. seed coat color genotypes,J Agric Food Chem,51,7879,83
[10] Choung MG, Choi BR, An YN, Chu YH, Cho YS. Anthocyanin profile of Korean cultivated kidney bean (Phaseolus vulgaris L.). J Agric Food Chem 2003; 51: 7040- 43.
[11] Granito M, Palolini M, Perez S. Polyphenols and antioxidant activity of Phaseolus vulgaris stored under extreme conditions and processed. LWT- Food Sci Technol 2008; 41: 994-99.
[12] LinLZ,HarnlyJM,Pastor-CorralesMS,LuthriaDL,,2008,The polyphenolic profiles of common beans (Phaseolus vulgaris L.),Food Chem,107,399,410
[13] MabalehaMB,,2004,YeboahSO. Characterization and compositional studies of the oils from some legume cultivars, Phaseolus vulgaris, grown in Southern Africa,J Am Oil Chem Soc,81,361,64
[14] CristianeRS,CâmaraCAU,VickiS.,Pinto,,Agriculture 2013,Beans (Phaseolus vulgaris L.) as a functional food: Implications on human health: Review,,3,90,111
[15] Fernandes MF, Mutch DM, Leri F. The relationship between fatty acids and different depression-related brain regions, and their potential role as biomarkers of responses to antidepressants. Nutrients 2017; 9(3): 298-339.
[16] Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat RevNeurosci 2014; 15: 771-85.
[17] HibbelnJR,,2014,Omega-3 fatty acid and nutrient deficits in adverse neurodevelopment and childhood behaviors,Child Adolesc Psychiatr Clin N Am,23,555,90
[18] SchmittF,LoefflerJP,,2014,,,02,,
[19] SinghS,NairV,JainS,GuptaYK,,2008,Evaluation of antiinflammatory activity of plant lipids containing α-linolenic acid,Indian Journal of Experimental Biology,46,453,56
[20] TeffKL,RickelsMR,GrudziakJ,,2013,Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease,Diabetes,62,3232,40
[21] Queiroz-MoniciK,CostaG,DaSN,ReisS,DeOA,,,,,,,
[22] ,2005,Bifidogenic effect of dietary fiber and resistant starch from leguminous on the intestinal microbiota of rats,Nutrition,21,602,09
[23] HeimlerD,VignoliniP,DiniM,RomaniA,,2005,Rapid tests to assess the antioxidant activity of Phaseolus vulgaris L. dry beans,J Agric Food Chem,53,3053,56
[24] BenninkM.,,2002,Consumption of Black Beans and Navy Beans (P. vulgaris) reduced azoxymethane-induced colon cancer in rats,Nutrition and Cancer,44,60,65
[25] StephenMB,MatthewEB,ThomasEW,BettyYS,StevenE,CarolH. Estrogenic,,2011,and antiestrogenic activities of phytolexins from rea kidney bean (Phaseolus vulgaris L.),J Agric Food Chem,59,112,20
[26] RamicaS.,,2014,Antidepressant activity of aqueous extract of Phaseolus vulgaris (black bean) in rodent models of depression,Int J Nutri Pharmacol Neurolog Dis,4,118,24
[27] KumarMR,JoshiSD,KulkarniVH,,2014,Evaluation of antibacterial and antitubercular activity of Phaseolus vulgaris Linn,International Journal of Pharma and Bio Sciences,5,219,24
[28] ,2015,Phytochemical screening and evaluation of analgesic and antiinflammatory activities of Phaseolus vulgaris Linn., seeds in rodents,J App Pharm Sci,5,66,9
[29] RitterAM,DomicianoTP,Verri JrWA,ZarpelonAC,da SilvaLG,BarbosaCP,Bersani-AmadoCA,,2015,Antihypernociceptive activity of anethole in experimental inflammatory pain,,,,
[30] ShiptonEA,,,Pain: Acute and chronic,,,,
[31] DewanSMR,AminMN,AdnanT,UddinSMN,Shahid-UdDaulaAFM,SarwarG,HossainMS,,2013,Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh,J Pharm Res,6,599,603
[32] BrulloC,BrunoO,BondavalliF,RaniseA,FilippelliW,,2006,-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities,Bio org Med Chem,14,1698,1705
[33] IsmailSM,RaoSKRS,BhaskarM,,2016,Evaluation of antiinflammatory activity of Boswelliaserrataon carrageenan induced paw edema in albino Wistar rats,Int J Res Med Sci,4,2980,6
[34] AshikaVP,SachinVS,VaishaliYL,YogeshAK,,,Acute toxicity study and anti-nociceptive activity of Bauhinia acuminate Linn. leaf extracts in experimental animal models,,,2320,6012
[35] ,2018,,Biomedicine & Pharmacotherapy,97,60,66
[36] OrhanI,KupeliE,SenerB,YesiladaE.,,2007,Appraisal of antiinflammatory potential of the clubmoss,Lycopodium clavatum L. J Ethnopharmacol,109,146,50
[37] ,2006,Guidance Document on Acute Oral Toxicity,,07,,
[38] KosterR,AndersonM,De Beer EJ,,1959,Acetic acid for analgesic screening,Fed Proc,18,418,20
[39] D' AmourFE,SmithDL,,1941,A method for determining loss of pain sensation,J Pharmacol ExpTher,72,74,8
[40] WinterCA,RisleyEA,NussGW,,1962,Carrageenan induced edema in rat paw as an assay for anti-inflammatory drugs,Proc Soc Exp Bio Med,111,544,47
[41] HijaziMA,El-MallahA,Aboul-ElaM,EllakanyA,,2017,Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors,Evidence-Based Complementary and Alternative Medicine,3,1,13
[42] EstherOA,OlufunmilayoOA,RakeshS. Analgesic,,2014,and anti-inflammatory effects of the methanol root extracts of some selected Nigerian medicinal plants,Pharm Biol,52,1208,16
[43] OwoyeleBV,BakareA O,,2018,Analgesic properties of aqueous bark extract of Adansonia digitata in Wistar rats,Biomedicine & Pharmacotherapy,97,209,12
[44] MannanMA,KhatunA,KhanMFH,,2017,Antinociceptive effect of methanol extract of Dalbergiasissoo leaves in mice,BMC Complementary and Alternative Medicine,17,1,13
[45] ShenawySM,Abdel-SalamOM,BaiuomyAR,BaeranSE,ArbidMS,,2002,Studies on the Anti-inflammatory and Antinociceptive effects of melatonin in rat,Pharmacol Res,46,235,43
[46] GrelaER,GunterKD,,1995,Fatty acid composition and tocopherolcontent of some legume seeds,Animal Feed Sci Technol,52,325,31
[47] ,2007,Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes,Plant Foods Hum Nutr,62,85,91
[48] Déciga-CamposM,Montiel-RuizRM,Navarrete-VázquezG,López-MuñozFJ,,2007,Palmiticacid analogues exhibiting antinociceptive activity in mice,Proc West Pharmacol Soc,50,75,7
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