Abstract:
Association characteristics of antidepressant drug Citalopram hydrobromide in water have been examined and its thermodynamic parameters have been calculated using tensiometery and conductometry. The critical micelle concentration (cmc) was determined by surface tension measurement at 30oC and Surface activity was studied by measuring surface parameters i.e. surface pressure, π, surface excess concentration, Γ, area per molecule of drug and standard Gibbs free energy of adsorption, ΔGoads. The electrical conductivity was measured as a function of concentration at various temperatures and cmc was calculated in the temperature range 20-50oC. Thermodynamic parameters i.e. standard free energy of micellization, ΔGom standard enthalpy of micellization, ΔGom and standard entropy of micellization, ΔGom were calculated from cmc value using closed association model.
Page(s):
1-6
DOI:
DOI not available
Published:
Journal: Journal of Chemical Society of Pakistan, Volume: 32, Issue: 1, Year: 2010