Thyroid disorder and association of insulin antibodies with thyroid antibodies in children with type 1 diabetes mellitus | [Pakistan Journal of Medical Research • 2023]

Author(s):

1. Muniba Jalil: Department of Pediatric Medicine, National Institute of Child Health, Karachi. Pakistan

2. Mohsina Noor Ibrahim: Department of Paediatric Endocrinology, National Institute of Child Health, Karachi. Pakistan

3. Sajid Ali: Department of Paediatric Surgery, National Institute of Child Health, Karachi. Pakistan

4. Sidra Saleem: Department of Pediatric Medicine, National Institute of Child Health, Karachi. Pakistan

5. Shahzadi Dilawar: Department of Pediatric Medicine, National Institute of Child Health, Karachi. Pakistan

6. Arit Parkash: Department of Pediatric Gastroenterology, National Institute of Child Health, Karachi. Pakistan

Abstract:

Background: During past decade, type 1 diabetes (T1DM) disease burden has increased among all ages, but the rapid growth was seen in young children. It is quite common to have coexistence of other autoimmune disorders among children having T1DM. Objective: To evaluate the frequency of thyroid dysfunction in children having T1DM and association of insulin antibodies with thyroid antibodies in TIDM. Study type, settings & duration: This cross-sectional study was performed at Department of Endocrinology, National Institute of Child Health, Karachi from June to December 2021. Methodology: Children of age 2-17 years with T1DM were enrolled for this the study. Patients' sociodemographic and clinical profile was documented in a pre-designed proforma. SPSS version 21 was used for statistical analysis. Results: Mean age of patients was 10.49±4.24 years. Out of 133 children, 59.4% were females. 18.79% were positive for Insulin autoantibody, while 16.5% were positive for IA-2 and 33.1% for generalized anxiety disorder (GAD). 22.6% of patients were positive for thyroid peroxidase (TPO) and 39.09% were positive for Tg-AB. A total of 84.2% of subjects had euthyroidism, 13.53% of subjects had hypothyroidism (subclinical or clinical) while 2.3% had hyperthyroidism. A significant association among the subjects with positive insulin autoantibodies and those with thyroglobulin antibodies was observed. Conclusion: A positive association between Insulin and Thyroglobulin antibodies suggests that patients with positive insulin antibodies are more likely to have thyroglobulin antibodies. Therefore, it is imperative to test and manage these markers on a frequent and regular basis to avoid the aggravation of the health of the patients suffering from type 1 diabetes mellitus.

Page(s): 3-7

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Research, Volume: 62, Issue: 1, Year: 2023

Keywords:

hypothyroidism , Hyperthyroidism , Type 1 diabetes mellitus , autoinsuline antibodies , antithyroid antibodies

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views