THE THERAPEUTIC effect OF OLEANOLIC ACID ON EXPERIMENTALLY INDUCED GASTROESOPHAGEAL REFLUX DISEASE | [Journal of Medical Science • 2021]

Author(s):

1. Eugene Jamot Ndebia: Faculty of Health Sciences, Department of Human Biology, Walter Sisulu University,Mthatha,South Africa

2. Kiddy Madikizela: Faculty of Health Sciences, Department of Human Biology, Walter Sisulu University,Mthatha,South Africa

3. Ikanyeng Dolly Seipone: Faculty of Health Sciences, Department of Human Biology, Walter Sisulu University,Mthatha,South Africa

4. Shauli Mathulo: Faculty of Health Sciences, Department of Human Biology, Walter Sisulu University,Mthatha,South Africa

Abstract:

Objective: This study was aimed to evaluate the therapeutic effect of Oleanolic acid (OA) on experimentally induced Gastroesophageal reflux disease (GERD). Materials and Methods: GERD was induced in twelve albino Wister rats by daily administration of 2 mL of acetic acid 15 %, pH: 2.41 for 30 days, while another group of three rats received the same volume of distilled water during the same period. The twelve rats being administered acetic acid were divided into four groups of three rats each and treated as follows; Group 1-the control group, with intra-peritoneal administration of 0.2 mL saline solution; Groups 2 and 3, with intra-peritoneal administration of 0.2 mL of OA 20 mg/kg and 40 mg/kg respectively and Group 4 with oral administration of 2 mL of Lansoprazole 20 mg/kg. All treatments were given simultaneously with the acetic acid daily for 30 days. All rats’ oesophagi were harvested for histological analysis. Results: Rats treated with 20 mg/kg and 40 mg/kg OA revealed a more intact oesophageal lining compared to the detached saline group one. There was no damage to blood vessels and the mucosal protective barrier was thick. Conclusion: Our results suggest that OA may protect the oesophagus against GERD

Page(s): 110-114

DOI: DOI not available

Published: Journal: Journal of Medical Science, Volume: 29, Issue: 2, Year: 2021

Keywords:

inflammation , therapy , Oesophagus , Oleanolic acid , Gastroesophageal reflux disease GERD

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views