Vascular Endothelial Growth Factor expression in peripheral blood of patients with pregnancy induced hypertension syndrome and its clinical significance. | [Pakistan Journal of Medical Sciences • 2014]

Author(s):

1. Yanfang Ren: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, China

2. Huiling Wang: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China

3. Haixia Qin: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China

4. Jun Yang: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China

5. Yuhong Wang: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China

6. Shan Jiang: Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China

7. Ying Pan: The Third First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China

Abstract:

Objective: This study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence. Methods: Double-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the peripheral blood of non-pregnant women (normal group, 30 cases), normal pregnant women (pregnancy group, 30 cases) and PIH patients (PIH group, 30 cases). Results: VEGF level in the pregnancy group was significantly higher than in the normal group, and the difference between these two groups was significant (P P P Conclusions: The significant decrease of VEGF level after pregnancy was possibly an important factor of PIH pathogenesis.

Page(s): 634-637

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 30, Issue: 3, Year: 2014

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