The effect of Gabapentin on Postoperative Pain, Morphine Sparing effect and Preoperative Anxiety in Patients Going for Sleeve Gastrectomy Surgical Procedure. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2019]

Author(s):

1. Mueen Ullah Khan: Department of Anesthesia, King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

2. Fahad Y. Bamehriz: King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

3. Mansoor Aqil: Department of Anesthesia, King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

4. Fatama Al Dammas: Department of Anesthesia, King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

5. Awatif Fadin: Department of Anesthesia, King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

6. Rashid Saeed Khokhar: Department of Anesthesia, King Khalid University Hospital College of Medicine, King Saud University, Riyadh, Saudi Arabia

Abstract:

Objective: To determine the effectiveness of preoperative administration of gabapentin in reduction of acute postoperative pain, morphine consumption and preoperative anxiety and sedation in obese patients undergoing laparoscopic sleeve gastrectomy. Study Design: Double-blinded randomised control trial. Place and Duration of Study: King Khalid University Hospital, King Saud University Riyadh, Saudi Arabia, from July 2014 to January 2017. Methodology: Fifty patients undergoing sleeve gastrectomy were enrolled in the study. The subjects received either 1200 mg gabapentin or placebo 2 hours before surgery. The amount of morphine consumption and postoperative pain at 4, 8,12,16, 20 and 24 hours of surgery were measured. Preoperative anxiety and sedation were recorded at 2 hours interval after the drug administration. Results: There was no significant difference in patient characteristics in both groups. 24 hours PCA morphine consumption was significantly lower in gabapentin group than in the placebo group, 15.08 ±4.55 vs. 27.80 ±2.51 (p=0.001). Preoperative VAS anxiety, pre- verses post-drug, was significantly lower in gabapentin group 5.80 ±1.11 vs. 3.52 ±1.00 (p=0.001) than in placebo group 6.08 1.28 vs. 6.28 1.24 (p=0.635). Preoperative sedation score was not different in both groups. Conclusion: Preoperative oral gabapentin was effective in reducing the postoperative pain, morphine consumption and preoperative anxiety in morbid obese patients undergone laparoscopic sleeve gastrectomy.

Page(s): 697-701

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 29, Issue: 8, Year: 2019

Keywords:

Analgesic opioid , Obesitymorbid

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