Amino acid linked bromobenzoyl thiourea derivatives: syntheses, characterization and antimicrobial activities. | [Journal of Chemical Society of Pakistan • 2016]

Author(s):

1. Ahmad Rahee: Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

2. Imtiaz-Ud-Din : Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

3. Amin Badshah: Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

4. Muhammad Khawar Rauf: Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

5. Muhammad Nawaz Tahir: Department of Physics, University of Sargodha, Sargodha, Pakistan

6. Khalid Mohammed Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

7. Abdul-Hameed : HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

8. Sohaila Andleeb: Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

Abstract:

Five new bromobenzoyl thiourea derivatives (1-5) linked with different amino acids were synthesized via the reaction of bromobenzoyl chloride with potassium thiocyanide and the corresponding amines. The synthetic compounds were characterized by single crystal XRD, IR and NMR (1H- and 13C-) spectroscopy in addition to elemental analysis and melting point determinations. These compounds were also preliminary analyzed for antifungal and antibacterial activity against different strains of fungi and bacteria, respectively. The data suggest that the compounds exhibited promising antimicrobial activity and may prove potential lead compounds as antimicrobial agent.

Page(s): 959-964

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 5, Year: 2016

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