The Influence of Physical Factors of the Production Environment on Protein Metabolism in the Body | [Archives of Pharmacy Practice • 2024]

Author(s):

1. Markha Suleymanovna Umarova: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov,

2. Zalina Sergeevna Akhyadova: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov,Grozny

3. Tanzila Osmanovna Salamanova: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov,

4. Zezag Ilm-Pashaevna Dzhamaldinova: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov

5. Zukhra Dzhamalayevna Taysumova: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov

6. Malika Ramzesovna Bekmurzaeva: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov, Grozny, Russia.

7. Madina Magamedovna Tapaeva: Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov, Grozny, Russia.

8. Anastasia Maksimovna Ivanushkina: Department of Therapy, Medical Institute, Tula State University, Tula, Russia

Abstract:

The negative effect of vibration, as the main physical production factor, should be thoroughly investigated. In this scientific work, the effect of general vibration on protein metabolism in the body is studied using the example of laboratory animals. 2 series of experiments were conducted on 30 white rats kept in the same conditions. At the same time, animals of group 1 were exposed to vibration, unlike animals of group 2. Animals of group 1 were exposed to a general vertical sinusoidal vibration with a frequency of 20 Hz with a vibration velocity of 126 dB for 4 hours daily for 8 weeks. The results of the studies did not reveal significant changes in the total protein content. However, there was a significant decrease in albumin in the content of protein fractions, as well as an increase in the fractions of a- and ?-globulins. It was found that by the end of the experiment, there was a decrease in the content of total amino acids in the blood serum of experimental animals: aspartic acid (P<0.05), proline (P<0.05), glycine (P<0.01), valine (P<0.05), methionine (P<0.05) and phenylalanine (P<0.001). It should be noted that, in general, there is a decrease in the number of hydrophobic (nonpolar) amino acids (valine, proline, phenylalanine, and methionine) and slightly polar uncharged, as well as negatively charged (aspartic acid).

Page(s): 23-27

DOI: 10.51847/irgtxJcQcC

Published: Journal: Archives of Pharmacy Practice, Volume: 15, Issue: 3, Year: 2024

Keywords:

Proteins , Protein metabolism , Vibrations , Physical factors of production , Negative factors of production

References:

[1] Tur JA,Bibiloni MDM .1891 .Anthropometry, body composition and resting energy expenditure in human. Nutrients, 10(8) : .

[2] Karpińska E,Moskwa J,Puścion-Jakubik A,Naliwajko SK,Soroczyńska J,Markiewicz-Żukowska R .2022 .Body composition of young women and the consumption of selected nutrients. Nutrients, 10(1) : 129.

[3] Yang B,Tang C,Shi Z,Gao L .2023 .Association of macronutrients intake with body composition and sarcopenic obesity in children and adolescents: A population-based analysis of the national health and nutrition examination survey (NHANES). , 10(10) : 2307.

[4] Fischer NH,Oliveira MT,Diness F .2023 .Chemical modification of proteins - challenges and trends at the start of the 2020s. Biomater Sci, 10(3) : 719-48.

[5] Gurevich VV .2019 .Protein multi-functionality: Introduction. Cell Mol Life Sci, 10(22) : 4405-6.

[6] Siegrist J .2021 .Psychosocial stress at work and disease risks: Scientific evidence and implications for practice. doi:10, 62(9) : 893-8.

[7] Dutta S,Gorain B,Choudhury H,Roychoudhury S,Sengupta P .2022 .Environmental and occupational exposure of metals and female reproductive health. Environ Sci Pollut Res Int, 10(41) : 62067-92.

[8] .2020 .-2019: A systematic analysis for the global burden of disease study 2019. Lancet, 6736(20) : 30752-2.

[9] Wang Z,Jiang Y,Shao X,Liu C .2023 .On-site measurement and environmental impact of vibration caused by construction of doubleshield TBM tunnel in urban subway. Sci Rep, 10(1) : 17689.

[10] Beben D,Maleska T,Bobra P,Duda J,Anigacz W. .2022 .Influence of traffic-induced vibrations on humans and residential building-A case study. Int J Environ Res Public Health, 10(9) : 5441.

[11] Park I,Kim S,Kim Y,Yun B,Yoon JH .2022 .Association between physical risk factors and sleep disturbance among workers in Korea: The 5th Korean working conditions survey. Sleep Med, 08 : 157-64.

[12] Debenedictis TA,Billing D,Milanese S,Furnell A,Tomkinson G,Thewlis D. .2020 .The impact of the mechanical whole-body vibration experienced during military land transit on the physical attributes underpinning dismounted combatant physical performance: A randomized controlled trial. J Sci Med Sport, 09(4) : 380-5.

[13] Thaper R,Sesek R,Garnett R,Acosta-Sojo Y,Purdy GT .2023 .The combined impact of hand-arm vibration and noise exposure on hearing sensitivity of agricultural/forestry workers-A systematic literature review. Int J Environ Res Public Health, 10(5) : 4276.

[14] Grossmann T,Steffan B,Kirsch A,Grill M,Gerstenberger C,Gugatschka M. Exploring .2021 .the pathophysiology of Reinke's Edema: The cellular impact of cigarette smoke and vibration. Laryngoscope, 10(2) : E547-54.

[15] Bhuiyan MHU,Fard M,Robinson SR M .2022 .Effects of whole-body vibration on driver drowsiness: A review. J Safety Res, 02 : 175-89.

[16] Viellehner J,Potthast W. .2021 .The effect of cycling-specific vibration on neuromuscular performance. Med Sci Sports Exerc, 10(5) : 936-44.

[17] Kia K,Fitch SM,Newsom SA,Kim JH .2020 .Effect of whole-body vibration exposures on physiological stresses: Mining heavy equipment applications. Appl Ergon, 10 : 103065.

[18] Bartel L,Mosabbir A .2021 .Possible mechanisms for the effects of sound vibration on human health. Healthcare (Basel), 10(5) : 597.

[19] Lawrence-Sidebottom D,Schmidt MA,Harvey DO,Van Dongen HPA,Davis CJ .2021 .Floor vibrations for motivation and feedback in the rat vibration actuating search task. PLoS One, 10(9) : .

[20] Minematsu A,Nishii Y. .2022 .Effects of whole body vibration on bone properties in growing rats. Int Biomech, 10(1) : 19-26.

[21] Koh ES,Lim JY .2023 .Impacts of whole-body vibration on denervated skeletal-muscle atrophy in rats. J Orthop Res, 10(12) : 2579-87.

[22] Krajnak K,Waugh S,Welcome D,Xu XS,Warren C,McKinney W .2022 .Effects of whole-body vibration on reproductive physiology in a rat model of whole-body vibration. J Toxicol Environ Health A., 10(23) : 953-71.

[23] Chen D,Kim S,Lee S,Lee JM,Choi YJ,Shin SJ .2021 .The effect of mechanical vibration on osteogenesis of periodontal ligament stem cells. J Endod, 08(11) : 1767-74.

[24] ISO .2024 .Noise measurement for the purpose of evaluating human exposure to noise. Method of measurements at workplaces. ru/document/1200140579 (Accessed on 15 Jun, : .

[25] Verevkina M,Goncharov V,Nesmeyanov E,Kamalova O,Baklanov I,Pokhilko A,Potr S J Food Sci A .2023 .Application of the Se NPs-Chitosan molecular complex for the correction of selenium deficiency in rats model. , 10(1) : 455-66.

[26] Belyaev NG,Rzhepakovsky IV,Timchenko LD,Areshidze DA,Simonov AN,Nagdalian AA .2019 .Effect of training on femur mineral density of rats. Biochem Cell Arch, 19(2) : 3549-52.

[27] Wu P,Lin S,Cao G,Wu J,Jin H,Wang C .2022 .Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications. J Hazard Mater, 10 : 129361.

[28] Bigman LS,Levy Y .2019 .Molecules defined by their trade-offs. Curr Opin Struct Biol, 11 : 50-6.

[29] Mesquita FS,Abrami L,Linder ME,Bamji SX,Dickinson BC .2024 .Mechanisms and functions of protein S-acylation. Nat Rev Mol Cell Biol, 10(6) : 488-509.

[30] Xue C,Li G,Zheng Q,Gu X,Shi Q,Su Y .2023 .Tryptophan metabolism in health and disease. Cell Metab, 06(8) : 1304-26.

[31] Comai S,Bertazzo A,Brughera M,Crotti S. .2019 .Tryptophan in health and disease. Adv Clin Chem, 08 : 165-218.

[32] Pirami H,Khavanin A,Nadri F,Tajpoor A,Mehrifar Y,Tirani ZM .2021 .The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: An experimental study. Arch Environ Occup Health, 10(9) : 764-73.

[33] Minematsu A,Nishii Y,Imagita H,Sakata S H .2019 .Possible effects of whole body vibration on bone properties in growing rats. Osteoporos Sarcopenia, 07(3) : 78-83.

[34] Nagdalian AA,Oboturova NP,Krivenko DV,Povetkin SN,Blinov AV,Verevkina MN .2019 .Why does the protein turn black while extracting it from insect biomass? J Hyg Eng Des. , 29 : 145-50.

[35] Ansori AN,Widyananda MH,Antonius Y,Murtadlo AA,Kharisma VD,Wiradana PA .2024 .A review of cancer-related hypercalcemia: Pathophysiology, current treatments, and future directions. J Med Pharm Chem Res, 435280(7) : 944-52.

[36] Thalacker-Mercer A,Riddle E,Barre L .2019 .Protein and amino acids for skeletal muscle health in aging. Adv Food Nutr Res, 08 : 29-64.

[37] Hoshi T,Heinemann S. .2001 .Regulation of cell function by methionine oxidation and reduction. J Physiol, 10 : 7793-11.

[38] Wei F,Locasale JW .2023 .Methionine restriction and antitumor immunity. Trends Cancer, 07(9) : 705-6.

[39] Newberne PM,Suphiphat V,Locniskar M .1990 .Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline. Nutr Cancer, 10(3-4) : 175-81.

[40] Wan J,Liu H,Chu J,Zhang H .2019 .Functions and mechanisms of lysine crotonylation. J Cell Mol Med, 10(11) : 7163-9.

[41] Azevedo C .2015 .Saiardi A. Why always lysine? The ongoing tale of one of the most modified amino acids. Adv Biol Regul, 09 : 144-50.

[42] Kodama M,Nakayama KI M .2020 .A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer. Bioessays, 10(12) : .

[43] Santoso KH,Wahyu S,Maulydia M. .2024 .Neutrophil gelatinase associated lipocalin as biomarker in predicting acute renal tubular injury following general anesthesia with sevoflurane on low-flow anesthesia. J Med Pharm Chem Res, 449596(10) : 1567-82.

[44] Setyawati AN .2024 .The role of oxidative stress in hypoalbuminemia nephropathy related to Nephrotic syndrome: A critical review. J Med Pharm Chem Res, 10(1) : 32-49.

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