Treatment outcome of hyperprolactinaemic infertility with carbegoline in sub Saharan Africa. | [Pakistan Journal of Medical Sciences • 2008]

Author(s):

1. Adesiyun Adebiyi Gbadebo: Ahmadu Bello University Teaching Hospital, Shika Zaria, Kaduna State, Nigeria

2. Ameh Nkiruka: Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Shika-Zaria Kaduna State, Kaduna, Nigeria

3. Ozed Williams Ijeoma: Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Shika-Zaria Kaduna State, Kaduna, Nigeria

4. Ojabo Austin: Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Shika-Zaria Kaduna State, Kaduna, Nigeria

5. Umar Hajara: Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Shika-Zaria Kaduna State, Kaduna, Nigeria

Abstract:

Objectives: Hyperprolactinaemia is a known cause of infertility. We explored the efficacy of carbegoline, the long acting dopamine agonist that was recently introduced into our medical practice. Methodology: Seventy six patients with infertility secondary to hyperprolactinaemia were studied over a period of 20 weeks each. All the patients had carbegoline twice weekly for eight weeks. Two dosage regimen were used based on the pretreatment prolactin level; less than 50ng/ml had 0.25mg twice weekly (n=58) and 50ng/ml and above 0.5mg twice weekly (n=18). Results: Normalization of prolactin level was achieved in 75 (98.7%) patients. At the end of the study period, there was resumption of menstrual flow in 10 (76.9%) of the 13 patients that were amenorrhoiec and all the 39 (100%) patients that were oligomenorrhoeic had their normal menstrual cycle restored. Resumption of ovulatory cycles occurred in 87.7% of those with anovulatory cycles. Of the 76 patients, 69 (90.8%) got pregnant during the 20 weeks study. However, out of the 69 that got pregnant, 13 (18.8%) got pregnant while on carbegoline therapy. There was no case of carbegoline resistance or discontinuation recorded in this study. Conclusion: Carbegoline is a cost effective first line therapy in the management of infertile women with hyperprolactinaemia.

Page(s): 512-516

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 24, Issue: 3, Year: 2008

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views