Author(s):
1. Nur Chusnaini Inayat:
Wahid Hasyim University, Semarang, Indonesia
2. Siti Nur Chasanah:
Wahid Hasyim University, Semarang, Indonesia
3. Dian Inayati:
Wahid Hasyim University, Semarang, Indonesia
4. Edward Kurnia Setiawan Limijadi:
Diponegoro University, Semarang, Indonesia
Abstract:
Background: Diabetes mellitus is a metabolic disorder caused by the pancreas not being able to produce enough of the hormone insulin, insulin action or both. The current treatment of diabetes mellitus with oral antihyperglycemic drugs and long-term insulin is feared to worsen the patient's condition so that alternative treatments using herbal ingredients such as Ambon banana peel are needed. Aim: To determine the effect of hydroethanol extract from Ambon banana peel (Musa paradisiaca L) on reduction of blood glucose levels in streptozotocin-induced type 2 diabetes mellitus rats. Methods:An experimental researchpre-test and post-test control group design using 24 male Wistar rats, which were divided randomly into 4 groups. Negative control, positive control, hydroethanol extract of Ambon banana peel dose 400 mg / KgBB, hydroethanol extract of Ambon banana peel dose 800 mg / KgBB treatment for 21 days (po). On the 36th day, blood was drawn through the orbital plexus to test blood glucose levels. Results:It was showed that the administration of hydroethanol extract of Ambon banana peel (Musa paradisiaca L) at a dose of 400 mg / kgBB was the optimal dose to reduce blood glucose levels in rats with type 2 diabetes mellitus (p = 0.032). Conclusion:Giving hydroethanol extract of Ambon banana peel at a dose of 400 mg / KgBW in rats induced by streptozotocin can significantly reduce blood glucose levels.
Page(s):
1278-1282
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 3, Year: 2020
Keywords:
Ambon banana peel
,
hydroethanol extract
,
blood glucose
,
Musa paradisiaca L
References:
References are not available for this document.
Citations
Citations are not available for this document.