Ameliorating effect of Lycopene and N-Acetylcysteine against Cisplatin-Induced Cardiac Injury in Rats | [Pakistan Veterinary Journal • 2022]

Author(s):

1. Asmaa Elsayed: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University,13736 Moshtohor, Toukh, Qaliobiya,Egypt

2. Ashraf Elkomy: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University,13736 Moshtohor, Toukh, Qaliobiya,Egypt

3. Mohamed Alkafafy: Department of Biotechnology, College of Science, Taif University,P.O. Box 11099, Taif 21944,Saudi Arabia

4. Reda Elkammar: Department of Histology, Faculty of Veterinary Medicine, Benha University,13736 Moshtohor, Toukh, Qaliobiya,Egypt

5. Sabreen Ezzat Fadl: Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University,Matrouh,Egypt

6. Ehab Yahya Abdelhiee: Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Matrouh University,Matrouh,Egypt

7. Ahmed Abdeen: Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qaliobiya,Egypt

8. Gehan Youssef: Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University,13736 Moshtohor, Toukh, Qaliobiya,Egypt

9. Hassan Shaheen: Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University,Matrouh,Egypt

10. Ahmed Soliman: Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza,Egypt

11. Mohamed Aboubakr: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University,13736 Moshtohor, Toukh, Qaliobiya,Egypt

Abstract:

Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer activities. This research investigated the possible protective effects of lycopene (LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in serum of the treated groups. In addition, CP resulted in a significant increase in malondialdehyde (MDA), as well as significant decreases in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in changes in cardiac histopathology and increased caspase-3 expression in cardiac tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and apoptosis induced by CP, through their antioxidant properties.

Page(s): 107-111

DOI: 10.29261/pakvetj/2021.035

Published: Journal: Pakistan Veterinary Journal, Volume: 42, Issue: 1, Year: 2022

Keywords:

Cardiac toxicity Caspase3 Cisplatin Lycopene N acetylcysteine Rats

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