Abstract:
Background and objectives:
Epilepsy is a neurological disorder in which the patient suffers with two or more unprovoked seizures. It is one of the most common
neurological disorders worldwide, affecting more than 70 million people. Currently various modes of effective treatments are
available, but still there are many cases that remain drug resistant. Hence, there is a need to explore herbal medications for the
treatment of drug resistant epilepsy.
Methods:
Recent reviews and research articles (2000-2022) from PubMed and Google Scholar have been explored.
Review:
Based on etiology, there are six categories of epilepsy: Genetic, Structural, Metabolic, Immune, Infectious, and Unknown epilepsy.
Temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) is one of the most common forms of structural epilepsy. Even though
several new anti-epileptic drugs (AEDs) have been discovered, but the treatment of some cases, especially TLE-HS remain resistant
to them. Surgery is one of the most effective treatment options for TLE-HS; however, this usually results in memory deficits, and
occasionally, intracranial hematoma, delayed hydrocephalus, subdural empyema, and visual field defects in patients.
Conclusion:
Hence, to overcome drug resistance, new pharmacological and herbal therapies are required. Animal trials are first step in the
development of new drugs, to study toxicity and efficacy of proposed drugs. Many herbs have anticonvulsant activity but remain an
under-explored treatment option for epilepsy. Further research on herbal extracts as a possible treatment for epilepsy needs to be
conducted.
Page(s):
58-67
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Neurological Sciences, Volume: 17, Issue: 3, Year: 2022
Keywords:
Animal Model
,
Epilepsy
,
neurological disorders
,
Herbal therapies
,
TLEHS