Abstract:
Background Carica Papaya leaves extract has become a competent herbal cure for dengue infection, which is comparatively based on observations. The systematic review aimed to critically observe and analyze the given evidence about the efficacy and safety of Carica Papaya leaves extract in the management of dengue fever comparatively from randomized clinical control trials. Methods Open DOAR, Biomed, Web of Science, JSTOR, Europe PMC, PubMed, Google Scholar, and Embase were being explored. Inclusion criteria included clinical trials like randomized and non-randomized with placebo or no treatment in the control group. Incomplete articles and researches not having proper findings related to papaya leaves extracts role in dengue fever were excluded. We assessed recovery or increase in platelet count and other favourable clinical indicators like duration of stay in hospitals, plasma leakage prevention, complications, and mortality. Results Eighteen studies were included from various countries like Pakistan, Malaysia, Indonesia, India. Ten studies showed a significant rise in platelet count in patients receiving Carica Papaya leaves extract and other remaining studies showed no significant difference. The majority of studies do not show severe adverse effects. In most studies, improvement in mean platelet counts between the first and fifth days of treatment (75% confidence interval 23.74-47.15 with 35.45 mean difference, three studies, 127 participants, and low-quality evidence). No other clinical outcomes were not available. Conclusions Comparatively, in most of the studies, papaya leaves extract has been shown a beneficial effect of significant increase p>0.001, while in some studies, it has been shown that hospital stay in patients treated with papaya leaves extract shows decreases. Most studies have clear evidence of an increase in blood platelet count, whereas in some cases, blood platelet does not further drop in dengue patients treated with papaya. There is a necessity for further studies comprising clinical trials examining the effect of Carica Papaya extract on plasma leakage and other severe dengue complications.
Page(s):
150-150
DOI:
DOI not available
Published:
Journal: International Food & Nutrition Conference" August 18th-20th, 2022, University of Swat, Swat (Book of Abstracts), Volume: 1, Issue: 1, Year: 2022
Keywords:
Dengue fever
,
thrombocytopenia
,
Papaya leaf extract
,
Thrombocytes
,
Dengue Haemorrhage Fever