Toxicological Evaluation of Sodium Serological Parameters of Wistar Rats Benzoate on Hematological And. | [International Journal of Agriculture and Biology • 2018]

Author(s):

1. Zulfiqar Ahmad: Department of Food Science and Technology, University College of Agriculture and Environmental Sciences, The Islamia University of Bahawalpur-63100, Pakistan

2. Riaz Hussain: University College of Veterinary and Animal Sciences, The Islamia University, Bahawalpur, Pakistan

3. Muhammad Riaz: Institute of Food Science & Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan-Pakistan: Department of Food Science and Biotechnology, College of Life Sciences, Sejong University 05006 Seoul, Republic of Korea

4. Tariq Ismail: Institute of Food Science & Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan, Pakistan

5. Syed Mubashar Sabir: Faculty of Agriculture, The University of Poonch, Rawalakot, Azad Kashmir, Pakistan

6. Shinawar Waseem Ali: Institute of Agricultural Sciences, University of the Punjab, Lahore, Pakistan

7. Khalil Ahmad: University College of Conventional Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

8. Muhammad Nadeem: COMSATS Institute of Information Technology, Mailsi Road, Off Multan Road, Ada Pir Murad, Vehari, Punjab, Pakistan

Abstract:

Sodium benzoate is extensively used for the preservation of huge number of food items and medicines at commercial scale. Present study was carried out to investigate in vivo potential toxic effects of sodium benzoate in male wistar rats. For the purpose, 60 sexually mature male wistar rats without any clinical and behavioral abnormalities were randomly allocated to five different groups (A-E). After 5 days of acclimatization, various doses of sodium benzoate were given orally to groups (BE) of experimental animals for a period of sixty days. The rats kept in group A served as control. The experimental rats were sacrificed at 20, 40 and 60 days of the study for collection of blood samples. Statistical analysis indicates that different hematological parameters including red blood cell counts, hemoglobin concentration and hematocrit values decreased significantly as compared with control group of animals while total white blood cell counts increased significantly at higher concentrations of sodium benzoate. Results on serum biochemical analysis showed elevated concentrations of different liver function tests (total bilirubin, AST and ALT), kidney function tests (urea and creatinine), cardiac enzymes (LDH, CPK and CKMB), serum malondialdehyde (MDA) while reduced concentrations of different parameters of lipid profile (cholesterol, triglycerides, LDL and HDL) and serum proteins (albumin, total protein) as compared to control group. In conclusion, the findings of current experimental study suggest that sodium benzoate exerted adverse effects on different blood biochemical parameters of experimental rats. Furthermore, these effects aggravated with increasing dose levels and length of study period.

Page(s): 2417-2422

DOI: 10.17957/IJAB/15.0781

Published: Journal: International Journal of Agriculture and Biology, Volume: 20, Issue: 11, Year: 2018

Keywords:

Keywords are not available for this article.

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