A comparative evaluation for soluble intracellular adhesion molecule-1, CEA and CA19-9 in serum of colon and gastric cancer patients. | [Hamdard Medicus • 2007]

Author(s):

1. Andalib Ali Reza: Immunology Department, Isfahan, Medical School, isfahan University of Medical Sciences (IUMS), Isfahan, Iran

2. Chasemian Safaie Hajeh: Immunology Department, Isfahan, Medical School, isfahan University of Medical Sciences (IUMS), Isfahan, Iran

3. Hashemi-Nia Javad: Immunology Department, Isfahan, Medical School, isfahan University of Medical Sciences (IUMS), Isfahan, Iran

4. Mokhtari Mojgan: Immunology Department, Isfahan, Medical School, isfahan University of Medical Sciences (IUMS), Isfahan, Iran

5. Babazadeb Shadi: Immunology Department, Isfahan, Medical School, isfahan University of Medical Sciences (IUMS), Isfahan, Iran

Abstract:

From adhesion molecule receptors on the surface of cancer cells, the carcinoembryonic antigen (CEA), carbohydrate antigen l9-9(CAI9-9) and Intercellular adhesion molecules-1 (ICAM-l)have utilized as molecule markers in some cancers including gastrointestinal malignancy. The limitation and the value of either of these, still need more sought for evaluation of the tumor progression. A group of’ 53 patients with either colon or gastric cancer selected for operation and 23 healthy matched individuals were selected as control. Their blood was taken before and after operation, and the proteins markers concentration was evaluated using radio-irnmunoassay technique. The histopathological procedures were performed on surgically removed samples and pathological features were correlated with the protein serum levels. The mean± std. serum concentrations of gastric and colon serum samples were designed for CEA 54.4±23 and 53±22.6 µg/l, for CAI9-9 8l±56 U/ml and 76±47, and for sICAM-l 701±189 and 761±205 ng/ml respectively. The levels of these markers decrease by a range from 14.5%- 47% three months after operation. In patient groups the levels of ICAM-l, CAI9-9 and CEA augmented by 4, 5 and 10 folds respectively. The patients with tumors, which were diagnosed with well- differentiated grade, had a higher level of sICAM-l than the tumors with moderate or poor differentiation. The similar finding was however not confirmed between CEA, CA 19-9 and tumor grade. A clinical value of sICAM-l as a tumor marker with more advantages than CA 19-9 and at least similar with CEA in colon and gastric cancer would be conclusive.

Page(s): 5-11

DOI: DOI not available

Published: Journal: Hamdard Medicus, Volume: 50, Issue: 1, Year: 2007

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