Abstract:
A study of the time dependent effect of cortisol on human and rat blood samples was carried out to observe the potential of this hormone on Pso -value, Hill Coefficient "n", 2,3-DPG, lactate, .ATP and Glucose concentrations with Hb and Hct values as well. The blood samples, treated with cortisol 10-7 mol/I, along with their controls, were kept incubated for 15, 30 and 60 minutes and the evaluations of the parameters were conducted after the respective time intervals. The results obtained showed a significant rise in Pse -value in case of rat experiments after 30 minutes of cortisol action, whereas in human this value was found slightly elevated after 15 minutes of hormone treatment. The significant elevations of 2,3-DPG and lactate concentrations, provide a clear cut evidence of cortisol induced stimulated glycolysis in both human and rat erythrocytes, although the maximum effect was observed at different time intervals i.e. 15 minutes for human and 30 minutes for rat. The rest of the parameters quoted above, however, showed no significant change.
Page(s):
21-31
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Pharmacology, Volume: 3, Issue: 1--2, Year: 1986