The association between rentiol binding protein 4 and peripheral neuropathy in type 2 diabetic patient | [Anaesthesia, Pain and Intensive Care • 2024]

Author(s):

1. Iman Ali Nafakhi: Department of Pharmacy, Al-Nuaman teaching hospital, Al-Rusafa Health Directorate, Baghdad, Ministry of Health,,Iraq

2. Nibras H. Abdalsada: Department of Pharmacology, College of Pharmacy, University of Kufa,,Iraq

Abstract:

Background & Objective : The most common microvascular consequence of diabetes is peripheral neuropathy. A very common ailment that has a significant impact on a patient's quality of life is peripheral neuropathy (PN). The purpose of this study was to look into the possible link between retinol binding protein 4 (RBP4) and peripheral neuropathy in individuals with type 2 diabetes mellitus (T2D), as the relationship between RBP4 and PN is sltil unclear. Methodology: We enrolled 152 participants who were matched for age and sex in a case control study during August and December 2023. There were 50 healthy controls, 50 diabetic patients without PN, and 52 diabetic patients with PN. ELISA was used to measure serum RBP4. Results: Diabetic individuals with PN had significantly greater serum levels of RBP4 than diabetic patients without PN (P ? 0.001). Increased age (r = 0.262, P ? 0.01), DM duration (r = 0.565, P ? 0.01), and BMI (r = 0.183, P ? 0.05) were all substantially linked with RBP4 levels. RBP4 levels exhibited a negative co rrelation with high-density lipoproteins (HDL) and a posivtie correlation with total cholesterol, triglycerides, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL). Conclusion: Elevated RBP4 level is strongly and independently linked with PN in type 2 diabetic patients, and may play an important role in PN progression. Abbreviations: DM - Diabetes mellitus; PN - peripheral neuropathy; PBP4 - retinol binding protein 4 ; T2D - type 2 diabetes mellitus

Page(s): 908-913

DOI: 10.35975/apic.v28i5.2563

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 28, Issue: 5, Year: 2024

Keywords:

Diabetes mellitus , Diabetes mellitus , peripheral neuropathy , Retinol binding protein 4

References:

[1] Mallet ML,Hadjivassiliou M,Sarrigiannis PG,Zis P .2020 .Role of oxidative stress in peripheral neuropathy. J Mol Neurosci, 70(7) : 1009-17.

[2] Daneshzad E,Farsad-Naeimi A,Heshmati J,Mirzaei K,Maghbooli Z,Keshavarz SA .2019 .Association between dietary antioxidants and adipokines in obese women. Diabetes Metab Syndr, 02(2) : 1369-73.

[3] Chevalier S,Blaner WS,Azais-Braesco V,Tuchweber B .1999 .Dietary restriction alters retinol and retinol-binding protein metabolism in aging rats. J Gerontol A Biol Sci Med Sci, 54(9) : B384-92.

[4] Bose KSC,Gupta SK,Singh S. .2012 .Is serum retinol-binding protein4 a predictor for diabetes in genetically high-risk populations. J Res Med Sci, 17(11) : 1015-9.

[5] Von Eynatten M,Lepper PM,Liu D,Lang K,Baumann M,Nawroth PP .2007 .Retinol-binding protein 4 is associated with components of the metabolic syndrome but not with insulin resistance in men with type 2 diabetes or coronary artery disease. Diabetologia, 50(9) : 1930-7.

[6] Xia M,Liu Y,Guo H,Wang D,Wang Y,Ling W. .2013 .Retinol-binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis via the PPARγ coactivator 1β-dependent pathway. Hepatology, 58(2) : 564-75.

[7] Majerczyk M,Kocełak P,Choręza P,Arabzada H,Owczarek AJ,Bożentowicz-Wikarek M .2018 .Components of metabolic syndrome in relation to plasma levels of retinol-binding protein 4 (RBP4) in older adults. J Endocrinol Invest, 41(10) : 1211-9.

[8] Elsherbeny AA,Abdel E,Abdel M,Elmahdi AR .2019 .Retinol-binding protein 4: possible relation to insulin resistance in type 2 diabetes and visceral obesity. J Metab Syndr, 8(2) : 2-6.

[9] Girona J,Amigó N,Ibarretxe D,Plana N,Rodríguez-Borjabad C,Heras M .2019 .HDL triglycerides: a new marker of metabolic and cardiovascular risk. Int J Mol Sci, 20(13) : 3151.

Citations

Downloads

Views