Abstract:
Objective: To assess the efficacy of myo-inositol and metformin alone or in combination with letrozol for inducing ovulation and achieving pregnancy in anovulatory women with polycystic ovary syndrome. Methodology: This randomized case-controlled study included 92 women with anovulatory polycystic ovarian syndrome with infertility of at least one year. They were divided into two groups; group 1 included 44 women who received metformin, inositol and letrozole and group 2 included 48 women who received metformin and inositol for 6 months. We assessed their effect on menstrual cycle, ovulation rate, pregnancy rate and serum testosterone. Results: Both groups had significantly shorter cycles following therapy (p = 0.004 and 0.003, respectively). In group 1, 32 out of 44 females ovulated, but in group 2, only 16 out of 48 females ovulated (72.7 vs. 33.3%, respectively). Pregnancy rate was similarly higher in group 1 (54.5 vs. 27.1%). After therapy, individuals in group 1 had significantly lower testosterone levels (55.16 ± 16.33 versus 59.15 ± 23.44; p = 0.044). Conclusion: We conclude that the combination of metformin and inositol with letrozol in patients with polycystic ovarian syndrome may generate a more positive outcome in terms of increased ovulation and pregnancy rate, restoration of menstruation and decreased hyperandrogenism
Page(s):
370-374
DOI:
DOI not available
Published:
Journal: Rawal Medical Journal, Volume: 48, Issue: 2, Year: 2023
Keywords:
Letrozole
,
metformin
,
Ovulation induction
,
Polycystic ovarian syndrome
,
inositol