Modelling Interrelationship between Aging and Learning in Drosophila melanogaster | [Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 • 2023]

Author(s):

1. Rabia Mahmood: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

2. Sukaina Arshad: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

3. Sami Karedia: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

4. Ayesha Aslam: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

5. Uzma Bukhari: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

6. Mushtaq Hussain: Dow College of Biotechnology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

Abstract:

The inverse relationship between aging and learning efficiency has long been known at finer physiological and genetic resolutions. Screening of intervening strategies in this regard require employment of an effective animal model system. Drosophila melanogaster has been successfully used to study the biology and impact of aging. However, to date, age-related changes in the learning behavior have not been explored in detail in D. melanogaster. In this investigation, innate behavior like negative geotaxis, positive phototaxis and learning abilities were compared in D. melanogaster from eclosion (day 0) to day 60 with ten days interval. Flies belonging to standard strain of D. melanogaster, W1118, were subjected to RING assay and T Maze assay to assess geotactic and phototactic behavior, respectively. Our data has shown statistically significant difference in the negative geotactic behavior in the flies of different ages. Gradual decline in the negative geotaxis was observed with increasing age in both genders. Both male and female flies of w1118 have also shown drop in positive phototaxis and learning behavior with increasing age especially beyond 30 days of eclosion. Histological examination of the fly brain points to the microanatomical changes representing increasing neurodegeneration with increasing age. The neurodegeneration varies in different anatomical compartments of the brain corresponding to the decline of neuro-coordination. In summary, the findings of the present study demonstrate that D. melanogaster could be an effective model to study age mediated changes in the learning and could be exploited to screening any therapeutic interventions.

Page(s):

DOI: DOI not available

Published: Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views