8p11 associated myeloid/lymphoid neoplasms: An illustrative case report of this rare entity and review of literature | [Journal of Pakistan Medical Association • 2020]

Author(s):

1. Naeem Jabbar: Department Pediatric Oncology, Indus Health Network, Karachi, Pakistan.

2. Neelum Mansoor: Indus Health Network, Karachi, Pakistan; Department of Haematology, Indus Health Network, Karachi, Pakistan.

3. Momal Taimoor: Indus Health Network, Karachi, Pakistan; Department of Haematology, Indus Health Network, Karachi, Pakistan.

4. Omer Jawed: Indus Health Network, Karachi, Pakistan; Department of Haematology, Indus Health Network, Karachi, Pakistan.

5. Muhammad Shamvil Ashraf: Department Pediatric Oncology, Indus Health Network, Karachi, Pakistan.

Abstract:

This report describes a unique case of 8p11 myeloproliferative syndrome (EMS), also known as stem cell leukaemia-lymphoma syndrome. A 13 years old male was referred from a tertiary care hospital after cervical lymph node biopsy. The disease mechanism of this neoplasm is to either evolve into acute myeloid leukemia or mixed lineage leukaemia, and less frequently of T or B lymphoid lineage. However, here we show a case of a rare simultaneous presentation of T lymphoblastic lymphoma on cervical lymph node and B lymphoblastic leukaemia on bone marrow biopsy along with t (8; 13) on karyotype testing.

Page(s): 743-746

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 70, Issue: 4, Year: 2020

Keywords:

Karyotype , T lymphoblastic lymphoma , t 8 , B lymphoblastic leukemia , FGFR1

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