Accuracy of haematology analyzer in the diagnosis of malaria in comparison with gold standard microscopy | [Journal of Islamabad Medical & Dental College • 2023]

Author(s):

1. Amna Imtiaz: Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan;Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

2. Noshina Noreen: Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

3. Syed Mudassar Ali Raza: Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

4. Sundas Ali: Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

5. Farah Hanif: Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan;Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

6. Rafay Ali Khan: Department of Pathology, Pakistan Atomic Energy Commission (PAEC) General Hospital, Islamabad, Pakistan

Abstract:

Objective: To assess the accuracy of Haematology analyzer in the diagnosis of malaria in comparison with gold standard microscopy. Methodology: A cross-sectional study was conducted at the Pakistan Institute of Medical Sciences and the Pakistan Atomic Energy Commission in Islamabad, Pakistan. The study was conducted for around six months, from May 2023 to October 2023. The Mindray BC-6200 haematology analyser was utilised to evaluate a total of 191 samples, comprising 127 samples from that were infected with malaria and 64 samples from healthy controls. When the presence of malaria parasites, identified as Plasmodium vivax and Plasmodium falciparum, was detected in dyed thick blood film, a microscopy examination was carried out as a reference. Analyse-it v4.92.3 was used to create the receiver operating characteristic (ROC) curve analysis. Results: The INR by BC-6200's sensitivity and specificity for P. falciparum and P. vivax infections. The sensitivity of the InR by BC-600 for P. falciparum and P. vivax was 27.9% and 85.5%, respectively. The specificity of the INR by BC-6200 for P. vivax and P. falciparum was 82.7% and 86.5%, respectively. The infection densities in microscopy varied statistically significantly between the various INR groups (?2 = 14.50, P 0.05). There was a significant difference (P<0.02) in the PLT count between the P. vivax/P. falciparum patient groups and the control group. Conclusion: The results imply that malaria might be screened for in a clinical setting using the BC-6200 haematology analyser "INR" flag and "INR#/INRg%" parameters.

Page(s): 237-243

DOI: 10.35787/jimdc.v12i4.1055

Published: Journal: Journal of Islamabad Medical & Dental College, Volume: 12, Issue: 4, Year: 2023

Keywords:

malaria , diagnostic accuracy , Light Microscopy , Mindray BC 6200 , Automated Haematology analyzer

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views