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Therapeutic Efficacy of Combination Therapy of L-methylfolate and Escitalopram in Depression.
Author(s):
1. Muhammad Siddique Kakar: Armed Forces Institute of Mental Health (AFIMH), National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
2. Salim Jehangir: Armed Forces Institute of Mental Health (AFIMH), National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
3. Mansoor Mustafa: Armed Forces Institute of Mental Health (AFIMH), National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
4. Haroon Khattak: Armed Forces Institute of Mental Health (AFIMH), National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
Abstract:
Objective: To evaluate the efficacy of L-Methylfolate in combination with Escitalopram compared to Escitalopram monotherapy in depression. Study Design: Randomized controlled trial. Place and Duration of Study: Armed Forces Institute of Mental Health (AFIMH) Rawalpindi, six months, from Jan 2015 to Jun 2015. Material and Methods: A total of 260 patients having a primary diagnosis of Major Depression with a score of more than 14 on the HAM-D (Hamilton rating scale for depression) scale were selected in this Randomized Controlled Trial. These patients were divided into two groups. Group A received Escitalopram 10mg with a placebo whereas group B received Escitalopram 10mg with L-Methylfolate in a dose of 15mg. Both were reassessed after one month and HAM-D scores were measured again. Results: Out of the total 260 patients, response was present in 184 (70.8%) and 76 (29.2%) did not respond to the treatment. Out of 130 patients that were treated with SSRI alone, 82 (63.1%) showed response to treatment while 48 (36.9%) did not respsond. Out of 130 patients that were treated with Escitalopram and L-Methylfolate, 102 (78.5%) showed response to treatment while 28 (21.5%) did not respond. The p-value with a confidence interval of 95% was found to be 0.006 showing that the difference in the two treatments was statistically significant. Conclusion: We concluded that a combination of SSRI and L-Methyfolate in depression may prove to be more effective than Escitalopram monotherapy.
Page(s): 976-981
DOI: DOI not available
Published: Journal: Pakistan Armed Forces Medical Journal, Volume: 67, Issue: 6, Year: 2017
Keywords:
Keywords are not available for this article.
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