The interrelation between HIV and condyloma acuminata high-risk strain | [Journal of Pakistan Association of Dermatologists • 2023]

Author(s):

1. Danu Yuliarto: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi General Hospital,Surakarta,Indonesia

2. Prasetyadi Mawardi: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi General Hospital,Surakarta,Indonesia

3. Muhammad Eko Irawanto: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi General Hospital,Surakarta,Indonesia

Abstract:

Objective The purpose of this study is to determine the relationship of high-risk HPV (HR-HPV) strain with IHC staining between HIV and non-HIV patients. Methods This study is cross-sectional research that involved 41 CA patients who underwent a biopsy to obtain histopathological data. A consecutive non-random sampling technique was used to select the subjects. The subjects were divided into CA with HIV and CA with non-HIV, we divide the subjects with ELISA examination. The IHC staining was subsequently performed to determine the HR-HPV strain. The finding was interpreted based on immunoreactive cells. Results The average age of the HR-HPV strains group was 31.20±16.87 years, and the average age of its negative strains was 33.19±12.41 years (p=0.931). HIV-positive patients were 5 (100%) with HR-HPV, yet none was found in HIV-negative. Conversely, 12 patients (33.3%) are HIV-positive patients with low risk (LR)-HPV and 24 HIV-negative patients (66.7%) with LR-HPV. Statistic results showed a significant relationship between HIV incidence and HR-HPV (p=0.005). Patients with negative HR-HPV have a 0.810 times lower risk of HIV than positive HR-HPV. Conclusion This study demonstrated that negative HR-HPV was a protective effect of HIV. CA patients with HIV infection were examined for high-risk CA strains with IHC staining to help determine prognosis and therapy.

Page(s): 876-882

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 33, Issue: 3, Year: 2023

Keywords:

Human immunodeficiency virus , Immunohistochemistry , human papillomavirus , Highrisk HPV strains

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