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Endophytes: Potential Source of Bioactive Compounds of Pharmaceutical Importance
Author(s):
1. Tahira Younis: Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan
2. Lubna Rehman: Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan
3. Sidra Rehman: Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan
4. Afnan Khan Shinwari: Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan
5. Irum Iqrar: Pakistan Academy of Sciences,Islamabad, Pakistan
6. Zabta Khan Shinwari: Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Pakistan Academy of Sciences, Islamabad, Pakistan
Abstract:
Microbes exists as mutualists, parasite, and symbiont or as pathogens in nature. In plant microbiota, plant immunity determines whether the interaction with microbes is friendly or hostile. Friendly interaction may have an eccentric way of mutual interrelations for a resource contribution. This interaction is called plant-endophyte mutualistic or symbiotic relation in which microorganisms (fungi, bacteria and actinomycetes) live within robust plant tissues. It has been discovered that almost all plant species investigated by various researchers harbor one or more endophytes. They benefit their host by producing various secondary metabolites that can be employed in agriculture and medicine. Endophytes are a treasure house of many novel bioactive compounds such as steroids, tannins, terpenoids, quinones, alkaloids, saponins and phenolic acids which makes them a potential candidate for anticancer, antibiotic, antioxidant, anti-inflammatory, antiviral, antidiabetic properties, etc. Endophytes continue to be the peculiar source of various potential drugs. This review intends to shed light on the function and potential applications of endophytes as a forthcoming source of medications for a range of illnesses/diseases as well as other potential medical uses.
Page(s): 1-13
DOI: DOI not available
Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 59, Issue: 4, Year: 2022
Keywords:
secondary metabolites , antimicrobial , Medicinal plants , antibiotics , endophytes , Pharmacology
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