The role of hematological markers in prediction of severity of psoriasis and associated arthritis | [Journal of Pakistan Association of Dermatologists • 2023]

Author(s):

1. Rezvan Amiri: Department of Dermatology, Kerman University of Medical Sciences,,Iran

2. Behzad Iranmanesh: Department of Dermatology, Kerman University of Medical Sciences,,Iran

3. Kiana Yazdizadeh: General Practitioner, Kerman University of Medical Sciences, Iran.

4. Saman Mohammadi: Department of Dermatology, Kerman University of Medical Sciences,,Iran

5. Maryam Khalili: Department of Dermatology, Kerman University of Medical Sciences,,Iran

6. Mahin Aflatoonian: Department of Dermatology, Kerman University of Medical Sciences,,Iran

Abstract:

Background Nowadays, role of hematologic markers including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as cost-effective and reliable tests, in recognition of chronic inflammatory and autoimmune diseases, as well as prediction of their prognosis has been elucidated. In this study we investigate role of these factors in prediction of severity of psoriasis and associated arthritis. Methods This is a retrospective cross-sectional study on thirty moderate-to-severe psoriasis patients, hospitalized in dermatology ward, and thirty aged- and sexed-matched healthy adults. NLR/PLR in psoriasis patients was compared to healthy controls. Furthermore, NLR/PLR of classic type of psoriasis was compared to other types of psoriasis (including psoriatic arthritis and erythrodermic psoriasis) by variance analysis. Correlation of demographic features with NLR/PLR was assessed via chi-square test and independent t test. Results Mean age of patients in psoriasis and control groups was 35.66±16.62 and 39.8±11.18, respectively. Psoriasis patients had significantly higher NLR/PLR compared to control groups (3.47±3.83 vs. 1.37±0.55 and 133.26±83.99 vs. 96.25±40.72, respectively). The highest and lowest NRL/PLR belonged to erythrodermic and vulgaris types, respectively. Moreover, there was no significant correlation between NLR/PLR and psoriasis patients, with or without underlying disease. Conclusion NLR/PLR can be a useful indicator for psoriasis severity and associated arthritis. It might be helpful in selection of type of treatment in psoriasis patients and employed as a prognostic factor in prediction of disease course and possible accompanied morbidities.

Page(s): 489-494

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 33, Issue: 2, Year: 2023

Keywords:

Abstract , psoriatic arthritis , eolgtPsoriasis , Hematological markers

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