Under starved conditions the expression pattern of hypothalamic kisspeptin/gpr54 and role of kisspeptin-10 in restoration of lh secretion in prepubertal ewes. | [Journal of Animal and Plant sciences • 2014]

Author(s):

1. J. Wang: College of Animal Husbandry and Veterinary Medicine, Liaoning Medical University, Jinzhou, 121001, China

2. L. Sun: College of Animal Husbandry and Veterinary Medicine, Liaoning Medical University, Jinzhou, 121001, China

3. T. Zhang: Snowdragon Beef Co, Ltd, Dalian, China

4. H. Zhou: College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China

5. J. Xu: College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China

6. Y. Lou: College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China

Abstract:

Kisspeptin and its receptor G protein-coupled receptor (GPR54) have been shown to play a crucial role in regulation of GnRH secretion. The objective of this study was to evaluate the role of Kisspeptin/GPR54 in inhibition of LH secretion of prepubertal ewe sunder feed restricted conditions. Three months old, female, Small Tail Han sheep, around 16.2 kg body weights were used in this study. During experiment I, in control group, ewes were fed with standard diet (n=4), while in feed restricted group, ewes were subjected to 40% restriction in daily feed intake (n=4). Thirty days later, blood serum and hypothalamus of all the animals were obtained to determine secretion level of LH, insulin, leptin and expression of KiSS-1 and GPR54. The results showed that feed restriction significantly decreased hypothalamic expression of KiSS-1 (P

Page(s): 1003-1007

DOI: DOI not available

Published: Journal: Journal of Animal and Plant sciences, Volume: 24, Issue: 4, Year: 2014

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