The antitumor effect of the combination of aconitine and crude monkshood polysaccharide on hepatocellular carcinoma | [Pakistan Journal of Pharmaceutical Sciences • 2021]

Author(s):

1. Fei Yao: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

2. Guo-Rong Jiang: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

3. Guo-Qiang Liang: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

4. Qin Yuan: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

5. Yang Zhu: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

6. Min Liu: Tumor department, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

7. Lu-Rong Zhang: Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou, Jiangsu Province,China

Abstract:

Aconitine, the main component in Radix Aconiti Lateralis Preparata, not only exerts the anti-tumor effect on Hepatocellular Carcinoma (HCC) but also damages on immune system. In the present study, Crude Monkshood Polysaccharide (CMP), another one natural composition component originated from the same herbal with aconitine, combined with aconitine to investigate the effects on HCC and immunity in vitro and in vivo. The combination of CMP and aconitine enhanced the ability of the immunocyte to kill the tumor cell in vitro and had an additive effect on antiHCC in vivo. Aconitine-CMP in combination improved the spleen weights, spleen index, thymus weights, thymus index. Elevated CD4+ T and CD8+ T cells and macrophages in spleen, decreased serum IL-6 level and increased serum IFN-? and TNF-a levels were observed in mice treated with the combination of aconitine and CMP compare with control group (P<0.05). Our results showed that the combination of aconitine and CMP exerts anti-tumor effect by directly killing tumor cells and enhancing the anti-tumor immune responses, which further implies that chemotherapy drugs combined with Chinese medicine immunopotentiator maybe a feasible and effective strategy for HCC.

Page(s): 971-979

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 34, Issue: 3, Year: 2021

Keywords:

hepatocellular carcinoma , Aconitine , immunological enhancement , crude monkshood polysaccharide

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