XRCC1 Arg280His polymorphism and glioma risk: A meta-analysis involving 1439 cases and 2564 controls. | [Pakistan Journal of Medical Sciences • 2013]

Author(s):

1. Weiqun Shu: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

2. Ziyuan Zhou: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

3. Jiaohua Luo: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

4. Zhiqun Qiu: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

5. Yan Wang: Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, China; Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

6. Liang Zhang: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

Abstract:

Objectives: Previous reports indicated that XRCC1 Arg280His polymorphism might be a possible risk factor for several cancers. Published studies on the association of XRCC1 Arg280His polymorphisms with glioma risk have yielded controversial results. The present study aimed to derive a more precise estimation of the relationship. Methodology: Meta-analyses assessing the association of XRCC1 Arg280His variation with glioma were conducted and subgroup analyses on ethnicity and source of controls were further performed. Eligible studies for the period up to May 2012 were identified. Results: A total of four case-control studies comprising 1439 cases and 2564 controls were selected for analysis. The overall data indicated no significant association of XRCC1 Arg280His polymorphism with glioma risk (His vs Arg: OR=1.05; 95%CI=0.88-1.25; His/His vs Arg/Arg: OR=1.42; 95%CI=0.87-2.29; dominant model: OR=1.00; 95%CI=0.82-1.22; recessive model: OR=1.41; 95%CI=0.88-2.25). Likewise, in the subgroup analysis regarding ethnicity and source of controls, no associations were observed. Conclusion: The results of the present study failed to suggest an association of XRCC1 Arg280His polymorphism with glioma risk. Further large and well-designed studies are needed to confirm this conclusion.

Page(s): 37-42

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 29, Issue: 1, Year: 2013

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