Use of intravenous anti-D in patients with refractory and relapsed immune thrombocytopenic purpura. | [Journal of Pakistan Medical Association • 2003]

Author(s):

1. R. Sajid: Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan

2. S. N. Adil: Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan

3. S. Fadoo: Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan

4. S. Sabir: Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan

5. M. Khurshid: Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan

Abstract:

To determine the response to IV anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi. A total of 23 patients with chronic ITP were treated with either anti-D or splenectomy as second line treatment. The patients were assessed for time to achieve a response to second line treatment, duration of response and adverse events. There were 12 patients in the anti-D group and 11 in the splenectomy group. The mean platelet count at presentation was 9,000/cumm.The mean age was 8.9 years and 13.0 years and the male to female ratio was 1:1 and 1:1.2 in anti-D and splenectomy group respectively. 54.5% of the patient in the anti-D group responded compared to 81.8% in the splenectomy group. Median time to achieve a response was 7 days in the anti-D group and 1 day in the splenectomy group. Mean time to relapse was 87.8 days in the anti-D group and 55.4 days in the splenectomy group. No adverse events were recorded for any of the infusions of anti-D and none of the patients had more than 0.5 gm Id fall in the hemoglobin level following anti-D). It was thus concluded that Anti-D is a relatively safe, convenient and effective therapy for chronic ITP and can be used as a splenectomy-sparing agent when treatment is clinically indicated.

Page(s): 537-538

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 53, Issue: 11, Year: 2003

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