Abstract:
Bacterial infections are becoming more common at an alarming pace throughout the world, posing a significant challenge to health practitioners. Staphylococcus aureus is a leading opportunistic human pathogen renowned for its ability to evade the immune system and cause a variety of different infections. In particular, methicillin-resistant strains of S. aureus (MRSA) are a global cause of hospital-associated (HA) and community-associated (CA) infections which can vary from superficial skin lesions, through deep seated abscesses to life threatening sepsis. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of healthcareassociated infections. Zirconia based nanomaterials have biomedical and biological properties i-e in drug delivery, anti-oxidant, anticancerous, and anti-microbial. In this study we have synthesized and characterized ZrO2 nanoparticles by honey mediated sol-gel method. The structural characterization of nanoparticles, surface morphology, crystalline structure was observed by FTIR, SEM, and XRD. The antimicrobial activity of ZrO2 has been checked InVitro, a synergistic effect was observed, so now we are developing a bacterial mouse (BALB/C) model for In-Vivo experiments. H&E staining would be used for the observation of infected mouse tissue. This technique is relatively environmentally friendly as no toxic material discharges into the environment. This mouse model would be applicable for the evaluation of novel antimicrobial treatments of ZrO2 NPs against superficial infections caused by S. aureus (MRSA).
Page(s):
74-74
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023