TREATMENT OUTCOME AND ADVERSE EFFECTS OF DRUG RESISTANT TUBERCULOSIS PATIENTS AT LARKANA AND SUKKUR TUBERCULOSIS CENTRES | [Pakistan Journal of Physiology • 2020]

Author(s):

1. Ayaz Ali Unar: Department of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University,Larkana, Pakistan

2. Abdullah Dayo: Department of Pharmaceutics University of Sindh, Jamshoro, Pakistan

3. Muhammad Ali Ghoto: Pharmacy Practice, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan

4. Khalida Unar: Department of Microbiology, Shah Abdul Latif University,Khairpur, Pakistan

5. Muhammad Ali Khokhar: Department of Pharmacology, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan

Abstract:

Background: Anti-tuberculosis drug resistant is a major public health problem worldwide. It arises due to improper use of anti-tuberculous drugs in susceptible TB patients. The objectives of this study were to evaluate treatment outcomes and adverse effects of drug resistant tuberculosis patients. Methods: A descriptive cross-sectional study was conducted in two Programmatic Management of Drug Resistant Tuberculosis (PMDT) sites of Sukkur and Larkana. The sociodemographic data was obtained by a set of questionnaire following WHO guidelines. Adverse drug effects and treatment outcome data was gathered from their medical files. Results: Of a total 938 patients, 535 (57.1%) were male and 403 (42.9%) were female. Their mean age was 35.95±14.4 years in Sukkur and 35.46±11 years in Larkana. Married patients were 69%, illiterate were 46.3%, farmers 36.8%, lower class 60.4%, and rural were 68.8% patients. Previously treated cases were 83%. The MDR-TB cases were 82.8%. Diabetes mellitus as co-morbidity was 11.2%, and 41.3% were smokers. The adverse effects developed in 68.4% patients. Overall successful treatment outcome rate was 53.9%. Conclusion: Treatment outcome of drug resistant TB patients was quite low, and 68.4% patients developed adverse effects. Artharlgia was the most common adverse effect.

Page(s): 17-20

DOI: DOI not available

Published: Journal: Pakistan Journal of Physiology, Volume: 16, Issue: 2, Year: 2020

Keywords:

Tuberculosis , Drug Resistant Tuberculosis , Adverse drug effects , Treatment failure

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