Test S of haplotype concordance and discordance. | [Pakistan Journal of Statistics and Operation Research • 2007]

Author(s):

1. Mahnaz Khattak: Jinnah College for Women, University of Peshawar, Peshawar, Pakistan

2. Shuhrat Shah: Department of Statistics, University of Peshawar, Peshawar, Pakistan

3. Salahuddin: Department of Statistics, University of Peshawar, Peshawar, Pakistan

Abstract:

The test presented here is based upon the proband and his/her affected as well as unaffected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, mean and variance of the test are derived under the null hypothesis of random inheritance of the disease. It is then applied to data set of varying size of sibships having at least one affected and one unaffected sibs to investigate the existence of linkage disequilibrium.

Page(s): 45-52

DOI: DOI not available

Published: Journal: Pakistan Journal of Statistics and Operation Research, Volume: 3, Issue: 1, Year: 2007

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