The impact of SARS-CoV-2 infection on patients with aortic stenosis | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2023]

Author(s):

1. Man Yao: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

2. Yaping Sun: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

3. Xiangdong Xu: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

4. Chunya Zhang: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

5. Hongsong Li: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

6. Xiao Han: Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences,Shanghai,China

Abstract:

Objective: To investigate the potential treatments for aortic stenosis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using bioinformatics and systems biology. Study Design: Observational study. Place and Duration of the Study:Jiading District Central Hospital a liated Shanghai University of Medicine & Health Sciences, Shanghai, China, from August to December 2022. Methodology: GSE147507 was chosen as theSARS-CoV-2 infection dataset from the Biotechnology Information (NCBI) GEO database, while GSE153555 was chosen as the dataset of patients with aortic stenosis (AS). This analysis predicted protein-drug interactions (PDIs) and found therapeutic compounds for AS and COVID-19. Results: One hundred and four DEGs were shared between the two datasets. Researchers built a PPI network to identify 10 hub genes from the network. Researchers discovered that COVID-19 and AS shared certain pathogenic pathways and found a relationship between hub genes and transcription factors and miRNAs, as well as a connection between hub genes and proposed treatments. Conclusion: Hub genes were identi ed as potential pathogenic pathways in SARS-CoV-2 infection and AS. In addition, new prescription medication options for treating both illnesses were provided.

Page(s): 1344-1348

DOI: 10.29271/jcpsp.2023.12.1344

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 33, Issue: 12, Year: 2023

Keywords:

COVID19 , Covid19 , SARSCoV2 infection , Di erentially expressed genes , Aortic stenosis , Drug molecule , Hub genGese , nedisease

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