A placebo-controlled clinical trial on nimesulide in Osteoarthritis. | [Journal of Surgery Pakistan • 2003]

Author(s):

1. Nighat Kafil: Department of Pharmacology, Basic Medical Sciences Institute JPMC, Karachi, Pakistan

2. Kausar Aamir: Department of Pharmacology, Basic Medical Sciences Institute JPMC, Karachi, Pakistan

3. Shah Murad: Department of Pharmacology, Basic Medical Sciences Institute JPMC, Karachi, Pakistan

4. Jamal Ara: Medical Ward V, JPMC, Karachi, Pakistan

5. Saadia Anjum: Isra University, Hyderabad, Sindh, Pakistan

Abstract:

Osteoarthritis is a chronic, progressive articular disorder characterized by pain. The prevalence of this most common joint disease rises with increasing age and occurs in approximately 85% of people between 75 to 79 year of age.Simple analgesics are useful in patients with mild disease, although nonsteroidal anti-inflammatory drugs (NSAID) are the main stay of therapy. Nimesulide is an NSAID that has demonstrated clinically significant anti-inflammatory, analgesic and antipyretic activity in a variety of painful inflammatory conditions, including osteoarthritis. We compared nimesulide with placebo in groups of 30 patients each and were able to see a highly significant improvement in the parameters of pain at rest, pain on movement and tenderness while placebo group showed non-significant improvement in all the symptoms in a study conducted for 90 days. Nimesulide was well tolerated with mild side-effects.

Page(s): 5-8

DOI: DOI not available

Published: Journal: Journal of Surgery Pakistan, Volume: 8, Issue: 2, Year: 2003

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