Total and differential leucocytes counts in normal and cimetidine, ranitidine and tiotidine treated rats. | [Pakistan Journal of Medical Research • 1996]

Author(s):

1. Rana Tariq Mahmud: Pharmacology Department, Punjab Medical College, Faisalabad, Pakistan

2. Hidayat Hussain Khan: Pharmacology Department, Allama lqbal Medical College, Lahore, Pakistan

3. Muhammadshoaib Akhtar: Physiology & Pharmacology Department, University of Agriculture, Faisalabad, Pakistan

4. Syed Jawwad Hussain: PMRC Research Centre, Punjab Medical College, Faisalabad, Pakistan

Abstract:

Total and differential leucocytes counts were determined in normal and cimetidine, ranitidine and tiotidine treated albino rats. The drugs cimetidine,ranitidine and tiotidine were given intramuscularly at the recommended human dose levels i.e. 5.71 mg; 2.14 mg and 1.42 mg/kg body weight respectively twice daily with an interval of twelve hours for five weeks. The data obtained showed that tiotidine caused an increase in the total leucocytic counts and cimetidine increased the number of monocytes only. Ranitidine had no effect on any of these parameters.

Page(s): 126-128

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Research, Volume: 35, Issue: 3, Year: 1996

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