A comparision of QT interval prolongation in covid 19 patients treated with hydroxycholoquin alone and in combination with azithromycin | [Pakistan Journal of Medical and Health Sciences • 2021]

Author(s):

1. GAUHAR RAHMAN: Cardiology department Category A Hospital,Batkhela Malakand,Pakistan

2. MOHAMMAD YAQOOB KHAN: Govt Zakir Khan Shaheed Hospital, Matta Swat, Pakistan

3. ZAHABIA MANZOOR: Farooq Hospital/ Akhtar Saeed Medical College, Lahore, Pakistan

4. IMRANA NAWAZ: FCPS Cardiologist,Punjab Institute of Cardiology,Lahore, Pakistan

5. GUL MEHNAZ: International Medical College,Abbottabad, Pakistan

6. KASHIF ALI SAMIN: Dept of Family Medicine, Khyber Medical University,Peshawar, Pakistan

Abstract:

Objective: The aim of this study is to compare the incidence of increase QT interval among COVID 19 patients treated with hydroxychloroquin alone and combination with azithromycin. Study Design: Retrospective Cohort Study Place and Duration: It is a multicenter study and conducted in cardiology departments of Farooq Hospital, Lahore, Govt Zakir Khan Shaheed Hospital Matta Swat and Category A Hospital, Batkhela Malakand for duration from March 2020 to February 2021. Methods: Total 100 Covid-19 patients of both genders were enrolled in this study. Patients details demographics age, sex and body mass index were recorded after taking informed written consent. Patients were divided into two groups. Group I had 50 patients and received hydroxychloroquin and group II (50 patients) received hydroxychloroquin with azithromycin. Outcomes among both groups were assessed in terms of increase QT interval. Complete data was analyzed by SPSS 24.0 version. Results: There were 32 (64%) males and 18 (36%) females in group I while in group II 30 (60%) males and 20 (40%) females. Mean age in group I was 57.65±9.87 years with mean BMI 28.18±4.23 kg/m2 and in group II mean age was 61.09±6.26 years with mean BMI 29.18±6.53 kg/m2. Hypertension was the most common co-morbidity found in 60%and 56% in group I and II followed by diabetes 26% and 28% among both groups. Prolong QTc was found among 10 (20%) cases in group I and in Group II 15 (30%) patients. Significantly QTc was increase in group II from 443.18±26.23 to 475.13±29.36 while in group I QTc increases from 442.37±33.25 to 468.09±26.37 ms. Among 15 cases in combination group 9 patients had change QTc of >500 milliseconds and 2 cases had QTc of > delta 60 ms while in monotherapy group 4 cases had change QTc of 500 milliseconds and 1 had > delta 60 milliseconds. Conclusion: We concluded in this study that prolonged QTc and change of QTc was significantly higher in COVID 19 patients who received treatment with combination of hydroxychloroquin and azithromycin as compared to the patients who received hydroxychloroquin only.

Page(s): 1675-1678

DOI: 10.53350/pjmhs211561675

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 15, Issue: 6, Year: 2021

Keywords:

QTc interval , COVID 19 , azithromycin , Hydroxychloroquin

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