Synthesis, Characterization and Anticancer Activity of Pyrazine-2-carboxamide Metal Complexes. | [Journal of Chemical Society of Pakistan • 2018]

Author(s):

1. Mohsin Ali: Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

2. Mansoor Ahmed: Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan

3. Syed Imran Ali: Department of Applied Chemistry & Chemical Technology, University of Karachi, Karachi-75270, Pakistan

4. Konatsu Kojima: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA

5. Pranav Gupta: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA

6. Majid Mumtaz: Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

7. Zhe Sheng Chen: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA

8. Syed Moazzam Haider: Industrial Analytical Center (ICCBS), University of Karachi, Karachi-75270, Pakistan

9. Muhammad Hanif: Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan

10. Ameer Hassan: Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan

11. Dong Hua Yang: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA

12. Zi Ning Lei: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA

Abstract:

We explore the synthesis of metal complexes of a renowned antituberculosis drug, pyrazinamide (PZ) with copper, ferrous, ferric, cobalt and manganese. A detailed characterization of the resulting complexes was performed for establishing their structures by using spectroscopic techniques like NMR, FTIR, PXRD and SEM. These compounds were also explored for anticancer activity on SNB-19, HCT-15, COLO-205, and KB-3-1 cell lines and were found to be non-or low toxicity as most of the tested compounds' IC50 > 100 µM. Scanning electron microscopy (SEM) revealed marked changes in the morphology after complexation. Compared to the pure PZ, an abrupt change in the morphological features of the complexes was likely caused by the chelating of PZ molecules with the metals. The micrographs of complexes depict a uniform matrix which indicates complete complex formation of with the drug uniformly dispersed at the molecular level. X-ray diffraction (PXRD) data suggested crystalline nature for the pure ligand and its corresponding complexes and this observation is well supported by morphological characterizations performed using Scanning Electron Microscopy.

Page(s): 690-701

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 40, Issue: 4, Year: 2018

Keywords:

Pyrazine2carboxamide Metal Complexes , Anticancer Activity

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