Translational Biomedical Research: Challenges and Solutions of Using Animal Models | [Journal of the College of Physicians and Surgeons Pakistan • 2025]

Author(s):

1. Shahid Akhtar Akhund: Department of Medical Education and Anatomy and Genetics, College of Medicine Alfaisal University,Riyadh, Kingdom of,Saudi Arabia

Abstract:

In translational research, utilisation of laboratory animal models contributes signi cantly to the understanding of human diseases, diagnostics, and therapeutics. Due to their genetic, anatomical, and physiological similarities to humans, their use allows for in vivo studies to assess the safety, e cacy, and side e ects of potential treatments before human trials. However, the relevance is often challenged by signi cant physiological and genetic di erences between species. Additionally, ethical concerns regarding the use of animals research and variability and reproducibility issues also arise due to di erences in strains, breeding practices, and housing conditions, complicating the consistency and reliability of experimental outcomes. To address these challenges, researchers are exploring alternative approaches such asin vitro models, organoids, and computational simulations, which o er promising and ethical substitutes for animal models. Despite these developments, animal models remain indispensable for certain investigations due to their ability to replicate complex biological processes and disease mechanisms. Collaborative e orts to standardise protocols and promote data sharing are essential to improve the reproducibility and translational value of animal research.

Page(s): 661-664

DOI: 10.29271/jcpsp.2025.05.661

Published: Journal: Journal of the College of Physicians and Surgeons Pakistan, Volume: 35, Issue: 05, Year: 2025

Keywords:

Animal models , Translational research , Challenges in translational research , Alternative to animal models

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