A correlation of serum inhibin with sperm count and sperm motility in fertile and infertile males. | [Biomedica • 2004]

Author(s):

1. A. S. Sheikh: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

2. A. Ameena: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

3. F. M. Alvi: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

4. G. Jaffery: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

5. M. Tayyab: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

6. N. A. Chaudhary: Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

Abstract:

Inhibin is produced by Sertoli cells of the testis, provides negative feedback on FSH secretion, and may prove to be an important marker for the functioning of seminiferous tubules. The purpose of this study was to examine the relationship between the spermatogenic function of the tests of subfertile men and the plasma concentrations of inhibin. The study was carried out on twenty infertile (or subfertile) males and ten age-matched control subjects with proven fertility. Infertile subjects were subdivided into oligospermic, normospermic and azoospermic on the basis of their sperm count. In infertile subjects mean serum inhibin concentration (30.4.± 22.2 pg/ml) was higher as compared to fertile subjects (25.2 ± 8.5 pg/ml), although the difference was not statistically significant (p > 0.05). Among the subgroups of infertile subjects mean serum inhibin level in azoospermics, who showed testicular atrophy on biopsy, was 8.2..± 1.1 pg/ml, which was significantly lower (p 0.001) while mean percentage of immotile sperms was significantly higher hi infertile than fertile subjects (p

Page(s): 10-15

DOI: DOI not available

Published: Journal: Biomedica, Volume: 20, Issue: 1, Year: 2004

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