Abstract:
Advanced glycation end-products (AGEs) are produced in human body when the reducing sugars bind to body proteins. AGE formation and accumulation in the body increases due to increased blood glucose levels, extreme inflammation, oxidative stress or reduced function of the kidney. Increased AGE level in body might result in obesity, diabetes and cardiovascular diseases. Different types of highly animated processed foods consist of large concentrations of AGEs which are partly absorbed in the gastrointestinal tract and contribute to the body’s AGE contents. This review intended to evaluate the effect of diet on advanced Glycation in humans and attempted whether eating of a prebiotic nutritional supplement can decrease circulating AGE levels, progress glucose control and oxidative stress in adults with pre-diabetes. This review of the recent evidence base was carried out to evaluate the association between nutritional AGE intake and chronic low grade inflammation and avenues for future nutrition research were suggested. It was concluded that there is inadequate evidence at present to endorse dietary AGE restriction to any patient group. This was due to the poor quality of most existing trials, their short duration, participant heterogeneity and use of non-validated methods to measure serum and food-derived AGEs. It also concluded a positive relationship between tissue AGE levels and chronological age, cigarette smoking, waist circumference and nutritional intake of meat and meat products. However, further research is required to determine whether frequent consumption of foods containing large quantities of dietary AGEs contribute to tissue AGE deposition in healthy individuals.
Page(s):
204-204
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023