Abstract:
Hyperlipidemia is characterized by high levels of fats in the body, which can lead to cardiovascular diseases. Diet-based therapy utilizing natural resources and their bioactive compounds has gained attention for treating various physiological conditions. Seeds, such as basil, chia, and flax seeds, are rich in phytonutrients and have been used to treat drug-induced hyperlipidemia. To prepare the seed extracts, a mixture of powdered seeds was shaken with 50% ethanol, 50% acetone, and aqueous solvents. The bioactive compounds were quantified using HPLC. The extracts were then subjected to antioxidant profiling, including total phenolic content (TPC), total flavonoid content (TFC), 2,2diphenyl-1-picrylhydrazyl (DPPH) assay, ferric reducing antioxidant power (FRAP), and hydrogen peroxide (H2O2) scavenging capacity. Biochemical and nutritional assessments were also conducted. A bioevaluation trial was performed on rats, where they were fed the powder of basil, chia, and flax seeds for sixty days. The study included both normal and hyperlipidemic rats. Parameters such as drink intake, feed intake, weight, serum cholesterol, LDL, HDL, triglyceride levels, basophils, packed cell volume, mean corpuscular hemoglobin, and lymphocytes were assessed. Hematological investigations were conducted, and the data obtained was subjected to statistical modeling. The results indicated that the ethanolic extract of chia seeds exhibited the highest TPC, TFC, DPPH, H2O2, and FRAP assay results. In the bioevaluation trial, it was observed that the induction of cyclosporine increased cholesterol levels while reducing HDL levels. However, the administration of basil, chia, and flax powder at a concentration of 25mg/kg body weight increased HDL levels and reduced LDL and cholesterol levels. Based on the findings of this study, it can be concluded that incorporating these seeds into a regular diet may reduce the risk of increased cholesterol levels and related heart disorders. However, further studies and clinical trials are necessary to validate and expand upon these results.
Page(s):
385-385
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Chia
,
basil
,
Flax Seeds
,
DrugInduced Hyperlipidemia